Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment, does not meet important criteria of today standard methods

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959
Report date:
1959

Materials and methods

Principles of method if other than guideline:
BASF-Test, see details in remarks on material and methods
GLP compliance:
no
Remarks:
pre GLP-study

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine)
EC Number:
229-962-1
EC Name:
2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine)
Cas Number:
6864-37-5
Molecular formula:
C15H30N2
IUPAC Name:
4-[(4-amino-3-methylcyclohexyl)methyl]-2-methylcyclohexan-1-amine

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: Lutrol
Doses:
no data
No. of animals per sex per dose:
21 animals (no gender stated)
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 47 mg/kg bw
Remarks on result:
other: original value: 50 µl/kg bw (conversion into mg/kg bw is based on the density d=0.94 g/cm3)
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion