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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Principles of method if other than guideline:
see details in remarks on material and methods
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
unchanged (no vehicle)
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
5 injections
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
ca. 47, 95, 189 mg/kg bw/injection (50, 100, 200 µl/kg bw/injection)
No. of animals per sex per dose:
5 (no gender stated)
Control animals:
no
Details on study design:
Post-exposure period: 16 days

Results and discussion

Effect levels

Sex:
not specified
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

All five animals of the high dose group died; no deaths were observed at the mid and low dose level. After approximately 10 days, the test substance perforated the skin after the application and was present at the skin surface.

Applicant's summary and conclusion