2,2,3,3,4,4,5,5-octafluoropentyl methacrylate

Endpoint summary

Description of key information

Experimental studies were conducted to determine the ecotoxicological effects of OFPMA; specifically:

-        Fish embryo toxicity (OECD Guideline 236);

-        Acute daphnia toxicity (OECD Guideline 202);

-        Chronic daphnia toxicity (OECD Guideline 211) of both OFPMA and its degradation product;

-        Freshwater algae inhibition (OECD Guideline 201); and

-        Activated sludge respiration inhibition (OECD Guideline 209).

The fish embryo toxicity (FET) study results were further supported by nine QSAR 96-hour acute fish toxicity predictions. 

A review of the ecotoxicological data set as a whole as identified algae to be the most sensitive aquatic species with a measured 72-hour algae EC50 value of 4.4 mg/L. Therefore, further aquatic vertebrate testing of OFPMA is not necessary to address the regulatory requirement.

Also, the chronic daphnia toxicity results of the OFPMA degradation product octafluoro-1-pentanol, which report a 21-day NOEC of 73 mg/L, the highest concentration tested, indicate that there is no chronic toxicity concern.