Registration Dossier
Registration Dossier
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EC number: 206-596-0 | CAS number: 355-93-1
Endpoint summary
Administrative data
Description of key information
Experimental studies were conducted to determine the ecotoxicological effects of OFPMA; specifically:
- Fish embryo toxicity (OECD Guideline 236);
- Acute daphnia toxicity (OECD Guideline 202);
- Chronic daphnia toxicity (OECD Guideline 211) of both OFPMA and its degradation product;
- Freshwater algae inhibition (OECD Guideline 201); and
- Activated sludge respiration inhibition (OECD Guideline 209).
The fish embryo toxicity (FET) study results were further supported by nine QSAR 96-hour acute fish toxicity predictions.
A review of the ecotoxicological data set as a whole as identified algae to be the most sensitive aquatic species with a measured 72-hour algae EC50 value of 4.4 mg/L. Therefore, further aquatic vertebrate testing of OFPMA is not necessary to address the regulatory requirement.
Also, the chronic daphnia toxicity results of the OFPMA degradation product octafluoro-1-pentanol, which report a 21-day NOEC of 73 mg/L, the highest concentration tested, indicate that there is no chronic toxicity concern.
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