Registration Dossier
Registration Dossier
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EC number: 201-549-0 | CAS number: 84-65-1
Endpoint summary
Administrative data
Description of key information
Additional information
Bioconcentration factors for Anthraquinone were estimated in GLP study Bioconcentration and elimination of 14C residues by Eastern oysters (Crassostrea virginica) exposed to Anthraquinone according to EPA OTS 797.1830 (Oyster Bioconcentration Test) (Fackler, P. H., 1989).
The concentration of 14C-residues in the tissue of oysters exposed to Anthraquinone at both treatment level, reached steady state by day 1 of the exposure period. The mean (95% confidence interval) steady-state bioconcentration factor (BCF) for 14C-residues in the tissues of oyster exposed to 7.1 and 0.78 µg/L Anthraquinone (Day 1 -17) were 140X (90X - 190X) and 110X (94X - 130X) respectively. Model calculation based on mean measured concentration of 7.1 and 0.78 µg/L Anthraquinone in the test solutions and corresponding concentration of 14C-residues in the tissue of the exposed oysters predict a bioconcentration factor for Anthraquinone in oysters tissue was independent of the exposure concentration.
Continued elimination of 14C-residues from oysters, after exposure to both 7.1 and 0.78 µg/L Anthraquinone, was observed throughout the depuration period. Half-life (50% elimination) of the 14C residues present in the oysters tissue during steady state (exposure days 1 -14) occur during the first 24 hours of the depuration period. After 14 days depuration, 93% and 87% elimination of 14C -residues present during steady-state had been achieved in oysters exposed to 7.1 and 0.78 µg/L Anthraquinone respectively.
The bioconcentration factor for AQ was also calculated using BCFBAF v3.00 as BCF of 21.15 L/kg; Log BCF from regression-based method = 1.325 (Ekotoxikologické centrum Bratislava, s.r.o., 2010).
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