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Toxicological information

Neurotoxicity

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Description of key information

Diethyl ketone did not induce changes in neurobehaviour and neuropathology when administered to rats for 120 days at a concentration of 1860 mg/kg bw/d in drinking water. 

Key value for chemical safety assessment

Additional information

In two subchronic toxicity studies diethyl ketone was administered to five female Wistar rats in drinking water for 120 days at a concentration of 2.4 % which corresponds to 1860 mg/kg bw/d (EPA/OTS,1983). In the first study detailed neurobehavioral examinations were performed, which consisted of observation of balance, strength, coordination, reflexes and behaviour. No alterations were noted during the study. The subsequent study focused on neurohistopathology. No neuropathological effects were noted in the tissues examined (dorsal root ganglia, spinal roots, sciatic nerve, brain, spinal cord, skeletal muscle).

Justification for classification or non-classification

The experimental data presented above do not indicate a neurotoxic potential. Thus classification and labelling is not required with respect to this endpoint.