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Environmental fate & pathways

Henry's Law constant

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For 1,6-Hexanediamine, N1,N1,N6,N6-tetramethyl-, propoxylated the Henry's Law constant is calculated to be 8.4E-18 to 5.5E-14 Pa·m3/mole, based on estimations of its main constituents. Substances with a Henry's Law constant of <100 Pa·m³/mole will not evaporate into the atmosphere from the water surface.

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In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided. For the assessment of 1,6-Hexanediamine, N1,N1,N6,N6-tetramethyl-, propoxylated (Q)SAR results were used for the Henry's law constant, by assessment of its main constituents. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be not entirely adequately fulfilled, because all major constituents do not fall into the applicability domain of this (Q)SAR. Nevertheless, since the 1PO-constituent, which is just outside the domain of this (Q)SAR, has a very low estimated Henry's law constant and the other constituents are larger molecules, slow evaporation of 1,6-Hexanediamine, N1,N1,N6,N6-tetramethyl-, propoxylated into the atmosphere from the water surface may be expected.