Registration Dossier
Registration Dossier
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EC number: 239-343-8 | CAS number: 15306-17-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption by oral and dermal route, low bioaccumulation potential and mostly excretion by urine.
Key value for chemical safety assessment
Additional information
Absorption
Based on its low molecular weight (414.38), solubility in water (0.4862 g/l at 23 °C and pH = 6.2) and log Kow between -1 and 4 (0.72) Tris(ethyl acetoacetato-O1',O3)aluminium is expected to be absorbed by gastrointestinal tract and by dermal route. Respiratory absorption is unlikely.
Distribution
Based on its water solubility and log Kow= 0.72 there is no concern regarding potential bioaccumulation of the substance ( threshold value regarding logKow for bioaccumulation alert is 4).
Metabolism
According to the QSAR prediction the complex Tris(ethyl acetoacetato-O1’,O3)aluminium is stable during the metabolism: the precipitation of Al(OH)3 is not expected even though the exchange of ethyl acetoacetate with other ligands present in the human organism can not be excluded. The hydrolysis of the ligand ethyl acetoacetate to acetoacetic acid and ethanol followed by first the decarboxylation to acetic acid and then the reduction to acetaldehyde may occur.
Excretion
Due to the high water solubility of the substance, after oral and dermal absorption Tris(ethyl acetoacetato-O1’,O3)aluminium is expected to be mostly excreted in the urine.
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