Registration Dossier
Registration Dossier
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EC number: 609-453-4 | CAS number: 37630-52-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- The number of animal's room was mistyped in the study plan.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 2-Propenoic acid, 2-cyano-3-(3,4-dimethoxyphenyl)-, (2E)-
- EC Number:
- 609-453-4
- Cas Number:
- 37630-52-7
- Molecular formula:
- C12H11NO4
- IUPAC Name:
- 2-Propenoic acid, 2-cyano-3-(3,4-dimethoxyphenyl)-, (2E)-
- Test material form:
- solid
- Remarks:
- powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Under the conditions of this study, the acute oral LD50 value of the test item was greater than 2000 mg/kg body weight in female CRL: (WI) BR rats.
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