Registration Dossier
Registration Dossier
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EC number: 237-600-9 | CAS number: 13863-31-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 48h Daphnia magna > 100 mg/l
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
No studies on the acute toxicity to aquatic invertebrates were performed on the substance under registration. Therefore, the available data on similar substances (3a-A(Na), 3a-A(NaK) and 2 -A) have been taken into account. Justification for Read Across is given in Section 13 of IUCLID.
For the similar substance water solubility is higher than for the substance under registration, therefore they are more bioavailable in the water compartment and can be considered as conservative examples. The chemical structures are very similar, with Tanimoto similarity higher than 95 %. Based on the OECD Toolbox modelling of the liver metabolisation, both the first two structures share the same monohyroxy derivative as main metabolite. Biological reactivity for the substance under registration is therefore not expected higher that the considered analogues substances.
The analogue substance 2 -A is part of another group, but has the same level of sulfonation and support the behaviour of all members of this category the uniform behaviour respect to Daphnia
For all the tested analogous a value of EC50 greater than 100 mg/l was set, thus for the substance under registration the limit value of 100 mg/l has been taken as representative EC50.
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