Registration Dossier
Registration Dossier
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EC number: 203-344-1 | CAS number: 105-90-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs of Geranyl propionate
- Author:
- D. L. J. Opdyke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology. Vol. 12, Pg. 897, 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute oral toxicity of 3,7-dimethylocta-2,6-dien-1-yl propanoate (105-90-8) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Geranyl propionate
- EC Number:
- 203-344-1
- EC Name:
- Geranyl propionate
- Cas Number:
- 105-90-8
- Molecular formula:
- C13H22O2
- IUPAC Name:
- geranyl propionate
- Details on test material:
- - IUPAC Name: 3,7-dimethylocta-2,6-dien-1-yl propanoate
- Common Name: Geranyl propionate
- Mol. formula: C13H22O2
- Molecular Weight: 210.3148 g/mol
- Smiles: CCC(=O)OC\C=C(/C)\CCC=C(C)C
- InChI: 1S/C13H22O2/c1-5-13(14)15-10-9-12(4)8-6-7-11(2)3/h7,9H,5-6,8,10H2,1-4H3/b12-9+
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: 3,7-dimethylocta-2,6-dien-1-yl propanoate
- Common Name: Geranyl propionate
- Mol. formula: C13H22O2
- Molecular Weight: 210.3148 g/mol
- Smiles: CCC(=O)OC\C=C(/C)\CCC=C(C)C
- InChI: 1S/C13H22O2/c1-5-13(14)15-10-9-12(4)8-6-7-11(2)3/h7,9H,5-6,8,10H2,1-4H3/b12-9+
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed in treated rat at 5000 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be >5000 mg/kg bw, when rats were treated with 3,7-dimethylocta-2,6-dien-1-yl propanoate (105-90-8) orally.
- Executive summary:
Acute oral toxicity study was conducted by using 3,7-dimethylocta-2,6-dien-1-yl propanoate (105-90-8) in rats at the concentration of 5000 mg/kg bw. No Mortality was observed at dose 5000 mg/kg bw. Therefore, LD50 was considered to be >5000 mg/kg bw, when rats were treated with 3,7-dimethylocta-2,6-dien-1-yl propanoate (105-90-8) orally.
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