.beta.-D-Ribofuranoside, methyl 2,3-O-(1-methylethylidene)-, 5-(4-methylbenzenesulfonate)

Surface tension

Administrative data

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 09, 2005 to June 16, 2005

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

This study was conducted in compliance with the Swiss Ordinance relating to Good Laboratory Practice, adopted February 2", 2000 [RS 813.016.51. This Ordinance is based on the OECD Principles of Good Laboratory Practice, as revised in 1997 and adopted November 26'", 1997 by decision of the OECD Council [G(97)1861Final].

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2005

Report date:

2005

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

OECD harmonised ring method

Test material

Test material information

Constituent 1

Reference substance name:

[(3aS,4S,6S)-6-methoxy-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl 4-methylbenzene-1-sulfonate

EC Number:

609-920-2

Cas Number:

4137-56-8

Molecular formula:

C16H22O7S

IUPAC Name:

[(3aS,4S,6S)-6-methoxy-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl 4-methylbenzene-1-sulfonate

Details on test material:

Identity: Tosylfuranosid
Appearance: Solid / white
Storage: At room temperature at about 20°C
Expiration Date: July 31, 2005

Results and discussion

Surface tension

Surface tension:

>= 62.41 - <= 62.66 mN/m

Temp.:

20.3 °C

Remarks on result:

other: concentration = 90% of saturation concentration

Applicant's summary and conclusion

Conclusions:

The surface tension of Tosylfuranosid in water (90 % of saturation concentration) was determined to be 62.5 mN/m at 20.3°C.
Based on the criteria as outlined in the EEC Guideline, Tosylfuranosid is not a surface active substance.

Executive summary:

The purpose of the study was to evaluate the surface tension of an aqueous solution of Tosylfuranosid by means of a ring tensiometer.

The reduction in surface tension of water, by dissolving a substance in it, indicates whether the substance is surface-active or not. Knowledge of this property is useful to assess the environmental impact of a substance.

The determination of the surface tension of an aqueous solution of Tosylfuranosid was based on the OECD Guideline No. 115: "Surface Tension of Aqueous Solutions" (1995) and on the EEC Directive 92/69, Part A, Methods for the determination of physico-chemical properties, A.5 “Surface tension”, EEC Publication No. L383, December 1992.

The calibration factor fb was determined to be 1.0127 for double distilled water. The data are part of RCC's instruments' files and a copy is presented in the raw data of the present study.

Individual measurements for the surface tension of the aqueous test item solution were performed. From these, the mean and the corrected value for the given solution were calculated. The tabulated values represent rounded results obtained from calculation using the exact raw data.

In conclusion, the surface tension of Tosylfuranosid in water (90 % of saturation concentration) was determined to be

62.5 mN/m at 20.3°C.

Based on the criteria as outlined in the EEC Guideline, Tosylfuranosid is not a surface active substance.