Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 11, 2005 to July 01, 2005
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
OECD Guideline for Testing of Chemicals No. 107: “Partition coefficient (n-octanol/water): Shake Flask Method”; adopted July 27, 1995. OECD Guideline for Testing of Chemicals No. 117: “Partition coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method”; adopted March 30, 1989. EEC Directive 92/69, Part A, Methods for the determination of physico-chemical properties, A.8 “Partition coefficient”, EEC Publication No. L383A, December 1992.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl 2,3-O-(1-methylethylidene)-5-O-[(4-methylphenyl)sulfonyl]-ß-D-ribofuranoside
EC Number:
609-920-2
Cas Number:
4137-56-8
Molecular formula:
C16H22O7S
IUPAC Name:
Methyl 2,3-O-(1-methylethylidene)-5-O-[(4-methylphenyl)sulfonyl]-ß-D-ribofuranoside
Details on test material:
Identity: Tosylfuranosid
Appearance: Solid / white
Storage: At room temperature at about 20°C
Expiration date: July 31, 2005

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
1.4
Temp.:
20 °C
pH:
>= 3.71 - <= 4.34

Applicant's summary and conclusion

Conclusions:
The partition coefficient of Tosylfuranosid was determined to be log POW = 1.4 using the flask shaking method.
Executive summary:

The purpose of the study was to evaluate the partition coefficient of Tosylfuranosid between n-octanol and water (log POW). The partition coefficient provides a rational basis for the assessment of the potential bioaccumulation of the test item.

The partition coefficient of Tosylfuranosid was determined to be log POW = 1.4 using the flask shaking method.