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EC number: 609-920-2 | CAS number: 4137-56-8
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 11, 2005 to July 01, 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- OECD Guideline for Testing of Chemicals No. 107: “Partition coefficient (n-octanol/water): Shake Flask Method”; adopted July 27, 1995. OECD Guideline for Testing of Chemicals No. 117: “Partition coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method”; adopted March 30, 1989. EEC Directive 92/69, Part A, Methods for the determination of physico-chemical properties, A.8 “Partition coefficient”, EEC Publication No. L383A, December 1992.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- [(3aS,4S,6S)-6-methoxy-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl 4-methylbenzene-1-sulfonate
- EC Number:
- 609-920-2
- Cas Number:
- 4137-56-8
- Molecular formula:
- C16H22O7S
- IUPAC Name:
- [(3aS,4S,6S)-6-methoxy-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl 4-methylbenzene-1-sulfonate
- Details on test material:
- Identity: Tosylfuranosid
Appearance: Solid / white
Storage: At room temperature at about 20°C
Expiration date: July 31, 2005
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 1.4
- Temp.:
- 20 °C
- pH:
- >= 3.71 - <= 4.34
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of Tosylfuranosid was determined to be log POW = 1.4 using the flask shaking method.
- Executive summary:
The purpose of the study was to evaluate the partition coefficient of Tosylfuranosid between n-octanol and water (log POW). The partition coefficient provides a rational basis for the assessment of the potential bioaccumulation of the test item.
The partition coefficient of Tosylfuranosid was determined to be log POW = 1.4 using the flask shaking method.
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