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Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

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Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
K1 from publicly available IUCLID 2003 file, study not available to confirm K1
Qualifier:
according to guideline
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Deviations:
no
GLP compliance:
yes
Analytical monitoring:
yes
Test organisms (species):
Daphnia magna
Water media type:
freshwater
Key result
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
> 1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
immobilisation
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.25 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Key result
Duration:
21 d
Dose descriptor:
LOEC
Effect conc.:
0.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Key result
Duration:
21 d
Dose descriptor:
other: maximum acceptable toxicant concentration (MATC)
Effect conc.:
0.38 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Details on results:
After 21 days, immobilization did not exceed 40% in any exposed group.

Consistent and statistically significant effects on reproductive performance and growth were observed at the nominal concentrations of 0.5 and 1.0 mg/l. No significant effects were observed at lower concentrations.
Validity criteria fulfilled:
yes
Conclusions:
1-naphthol tested in a 21-day Daphnia magna study gave an EC 50 > 1 mg/L (immobilization), NOEC 0.25 mg/L (reproduction rate), LOEC 0.5 mg/L (reproduction rate) and MATC 0.38 mg/L (reproduction rate).
Executive summary:

1-naphthol tested in a 21-day Daphnia magna study gave an EC 50 > 1 mg/L (immobilization), NOEC 0.25 mg/L (reproduction rate), LOEC 0.5 mg/L (reproduction rate) and MATC 0.38 mg/L (reproduction rate).

Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Principles of method if other than guideline:
calculation
Duration:
21 d
Dose descriptor:
other: ChV
Effect conc.:
0.583 mg/L
Remarks on result:
other: ECOSAR v1.11 calculation, Phenols class
Validity criteria fulfilled:
not applicable
Conclusions:
The calculated (ECOSAR v1.11, Phenols class) ChV (21d) is 0.583 mg/L, in line with the experimental 21-day Daphnia magna study NOEC 0.25 mg/L (reproduction rate)
Executive summary:

The calculated (ECOSAR v1.11, Phenols class) ChV (21d) is 0.583 mg/L, in line with the experimental 21-day Daphnia magna study NOEC 0.25 mg/L (reproduction rate)

Description of key information

1-naphthol tested in a 21-day Daphnia magna study gave an EC 50 > 1 mg/L (immobilization), NOEC 0.25 mg/L (reproduction rate), LOEC 0.5 mg/L (reproduction rate) and MATC 0.38 mg/L (reproduction rate).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.25 mg/L

Additional information