1-naphthol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1980

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1980

Materials and methods

Test guideline

Version / remarks:

Not specified

Principles of method if other than guideline:

General description has several elements of scientific requirements for this type of study

GLP compliance:

not specified

Test type:

traditional method

Test material

Test material information

Constituent 1

Reference substance name:

1-naphthol

EC Number:

201-969-4

EC Name:

1-naphthol

Cas Number:

90-15-3

Molecular formula:

C10H8O

IUPAC Name:

naphthalen-1-ol

Test material form:

solid

Specific details on test material used for the study:

Test item is identified with the CAS number from the information given in the IUCLID2003 Dataset.

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Details on inhalation exposure:

Two types of doses / exposures are mentioned. One under the L0 determination (Saturated atmosphere of chemical vapor), and another under the LC50 determination (Saturated atmosphere of mist, vapor and decomposition products) as described under the study design

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

6 h

Concentrations:

Not specified

No. of animals per sex per dose:

Not specified

Control animals:

not specified

Details on study design:

Exposure type: Saturated atmosphere of chemical vapor:

Substantially saturated vapor was prepared by spreading 50-100 grams of 1-naphthol over a 200 cm2 area on a shallow tray placed near the top of a 120 liter plexiglas chamber which is then sealed for at least 16 hours while an intermittently operated fan agitates the internal chamber atmosphere. Rats were then introduced into a gasketed drawer-type cage designed and operated to minimize vapor loss. Animals were exposed for six (6) hours and observed for mortality and toxicity for 14 days.

Exposure type: Saturated atmosphere of mist, vapor and decomposition products:

1-naphthol was heated to 179 degree C. Air was passed over the heated sample and mist, vapor, and any oxidation products generated were delivered to rats in a 9 liter glass exposure chamber. Animals were exposed for six (6) hours. Animals were observed for mortality and toxicity for 14 days.

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

LC0

Exp. duration:

6 h

Remarks on result:

not determinable

Remarks:

No mortality or signs of toxicity in rats exposed to a saturated vapor atmosphere.

Effect levels 2

Sex:

not specified

Dose descriptor:

LC50

Exp. duration:

6 h

Remarks on result:

not determinable

Remarks:

No mortality when rats exposed to s saturated vapor atmosphere of heated 1-naphthol. Signs of toxicity included eye irritation and hypoactivity

Mortality:

None

Clinical signs:

other: Signs of toxicity included eye irritation and hypoactivity when rats were exposed for 6 hours to a saturated vapor atmosphere of heated 1-naphthol.

Body weight:

Not described

Gross pathology:

Not described

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Remarks:

STOT SE Cat 3 (Note, this is also a harmonized classification)

Conclusions:

LC50 not determinable as the concentrations were not provided. However, STOT SE Cat 3 was assigned per UN GHS due to the eye irritation and hypoactivity from exposure to heated saturated vapor. No mortality reported.

Executive summary:

Rats were exposed for 6 hours with saturated atmosphere of 1 -naphthol or a saturated atmosphere of mist, vapor, and decomposition products of heated (179 degrees C) 1 -naphthol. The LC50 was not reported and the exposure concentrations were not provided. No deaths occured. The results cannot be used for Acute Toxicity - inhalation classification. However, STOT SE Cat 3 was assigned per UN GHS due to the hypoactivity from exposure to heated saturated vapor of 1 -naphthol.