Registration Dossier
Registration Dossier
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EC number: 946-945-0 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- (Q)SAR: endpoint-specific documentation on the prediction
- Principles of method if other than guideline:
- Estimation method HYDROWIN of “EPI Suite TM v4.10”, owned by the U.S. Environmental Protection Agency
- Preliminary study:
- n/a
- Transformation products:
- not measured
- Remarks on result:
- not measured/tested
- Remarks on result:
- not measured/tested
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- It can be concluded that d-Phenothrin is very stable against hydrolysis at neutral pH.
- Executive summary:
d-Phenothrin has a very low water solubility and an accurate measurement of the hydrolysis rate therefore is difficult.
A calculation was performed with the estimation method HYDROWIN of “EPI Suite TM v4.10”, owned by the U.S. Environmental Protection Agency, with the following results:
pH 8: The half-life for the reaction in water is estimated to be 199.5 days.
pH 7: The half-life for the reaction in water is estimated to be 5.4 years.
The HSDB (Hazardous Substances Data Bank) on Toxnet Toxicological Data Network, United States National Library of Medicine presents the following hydrolysis half-lives for d-trans Phenothrin:
pH 5: The half-life for the reaction in water is 301 days.
pH 7: The half-life for the reaction in water is 495 - 578 days.
pH 9: The half-life for the reaction in water is 91 - 120 days.
It can be concluded that d-Phenothrin is very stable against hydrolysis at neutral pH.
Reference
A calculation was performed with the estimation method HYDROWIN of “EPI Suite TM v4.10”, owned by the U.S. Environmental Protection Agency, with the following results:
pH 8: The half-life for the reaction in water is estimated to be 199.5 days. pH 7: The half-life for the reaction in water is estimated to be 5.4 years.
The HSDB (Hazardous Substances Data Bank) on Toxnet Toxicological Data Network, United States National Library of Medicine presents the following hydrolysis half-lives for d-trans Phenothrin:
pH 5: The half-life for the reaction in water is 301 days.
pH 7: The half-life for the reaction in water is 495 - 578 days.
pH 9: The half-life for the reaction in water is 91 - 120 days.
Description of key information
d-Phenothrin has a very low water solubility and an accurate measurement of the hydrolysis rate is difficult.
A calculation was performed with the estimation method HYDROWIN of “EPI Suite TM v4.10”, owned by the U.S. Environmental Protection Agency.
From the calculation, it has been concluded that d-Phenothrin is very stable against hydrolysis at neutral pH.
Key value for chemical safety assessment
Additional information
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