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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Principles of method if other than guideline:
Estimation of an inhalative LC50 value
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-mercaptoethanol
EC Number:
200-464-6
EC Name:
2-mercaptoethanol
Cas Number:
60-24-2
Molecular formula:
C2H6OS
IUPAC Name:
2-sulfanylethanol
Test material form:
liquid

Test animals

Species:
rat
Strain:
other: ChR-CD
Sex:
male
Details on test animals or test system and environmental conditions:
- Weight at study initiation: 243 - 304 g

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
The test substance was heated in a T-tube to ca. 100-125°C to insure complete vaporization; dry air stream carried the vapour to 8-liter bell jar containing 4 rats
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
975, 2030, 4060, 8100 and 16200 mg/m³ (300, 625, 1250, 2500 and 5000 ppm)
No. of animals per sex per dose:
4
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
ca. 2.03 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Mortality:
4/4 rats died at concentrations ≥ 1250 ppm (died during exposure in high dose groups or found dead 1 d after exposure at 1250 ppm); 2/4 rats died one d after exposure at 625 ppm; all rats survived in the low dose group. LC50 estimated (no calculation given by the authors).
Clinical signs:
other: During exposure of lethal concentrations rats showed red ears, inactivity, hyperpnea followed by dyspnea, pumping respiration, ruffled fur, fluid around the nose, discomfort, incoordination, tremor, convulsions, prolonged extension of body and limbs; afte
Gross pathology:
Rats that died during exposure showed congestion of various organs (vascular collapse). Edema and emphysema of the lungs in rats found dead the day after exposure. At 2500 ppm 2 rats showed yellow staining of liver sinusoids. No lesions in survivors.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
Findings indicate effects on central nervous system, respiratory and circulatory systems and possibly on the liver.