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EC number: 301-568-5 | CAS number: 94022-69-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of 2,7 Naphthalendisulfonic acid (3861-73-2) in rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of 2,7 Naphthalendisulfonic acid (3861-73-2) in rat
- Author:
- RTECS
- Year:
- 2 018
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of 2,7 Naphthalendisulfonic acid (3861-73-2) on rats.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- Trisodium 4-hydroxy-4-(4-anilino-5-sulphonato-1-naphthylazo)naphthalene-2,7-disulphonate
- EC Number:
- 223-378-0
- EC Name:
- Trisodium 4-hydroxy-4-(4-anilino-5-sulphonato-1-naphthylazo)naphthalene-2,7-disulphonate
- Cas Number:
- 3861-73-2
- Molecular formula:
- C26H16N3O10S3.3Na
- IUPAC Name:
- 2,7 Naphthalendisulfonic acid
- Details on test material:
- - Name of test material (IUPAC name): 2,7 Naphthalendisulfonic acid
- Common name: Anazolene sodium
- Molecular formula: C26H16N3O10S3.3Na
- Molecular weight: 695.591 g/mol
- Smiles notation: c12c(c(ccc1Nc1ccccc1)\N=N\c1c3c(cc(c1)S(=O)(=O)[O-])cc(S(=O)(=O)[O-])cc3O)cccc2S(=O)(=O)[O-].[Na+].[Na+].[Na+]
-InChl:1S/C26H19N3O10S3.3Na/c30-23-14-18(41(34,35)36)12-15-11-17(40(31,32)33)13-22(25(15)23)29-28-20-9-10-21(27-16-5-2-1-3-6-16)26-19(20)7-4-8-24(26)42(37,38)39;;;/h1-14,27,30H,(H,31,32,33)(H,34,35,36)(H,37,38,39);;;/q;3*+1/p-3/b29-28+;;;
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Anazolene sodium
- Molecular formula :C26H16N3O10S3.3Na
- Molecular weight :695.591 g/mol
- Substance type:organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- Details on study design:
- Other examinations performed: clinical signs - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at dose 8500 mg/kg bw in treated rats
- Clinical signs:
- other: Clinical signs like changes in urine composition, behavioral excitement ,dermatitis and other signs after systemic exposure were observed.
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be >5000 mg/kg bw,when rats were treated with 2,7 Naphthalendisulfonic acid (3861-73-2) orally.
- Executive summary:
Acute oral toxicity study was performed in rats using test material 2,7 Naphthalendisulfonic acid(3861-73-2).No mortality was observed at dose 5000 mg/kg bw.Clinical signs like changes in urine composition, behavioral excitement ,dermatitis and other signs after systemic exposure were observed. Hence,LD50 value was considered to be >5000 mg/kg bw,when rats were treated with 2,7 Naphthalendisulfonic acid(3861-73-2) orally.
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