Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information


In accordance with column 2 of REACH Annex VIII, the study does not need to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient), or the substance and its relevant degradation products decompose rapidly. 2-(2-aminoethoxy)ethanol (CAS 929-06-6) has a log Kow of -1.89 (@ 25 °C, uncharged molecule; estimated; see IUCLID-Chapter 4.7).


Estimates by the MCI method and the log-Kow method of KOCWIN v2.00 (EPISuite v4.11; BASF SE 2015) calculated for 2-(2-aminoethoxy)ethanol log Koc values of -0.02 (MCI) and -0.64 (log Kow).

However, the pKa of 9.62 (see IUCLID chapter 4.21) indicates that the substance will primarily exist as a cation in the environment. Cations generally adsorb stronger to soils containing organic carbon and clay than their neutral counterparts. Franco & Trapp (2008, 2009, 2010) have developed a method to take this effect into consideration when assessing the adsorption potential. The model is not yet validated; in addition, the applicability domain is not clearly defined. Nevertheless, the Koc values of the Franco & Trapp method give a good indication on the adsorption potential of a substance depending on the pH conditions of soil. The method is based on the dissociation constant pKa and the log Kow for the uncharged moelcule. The pKa of 2-(2-aminoethoxy)ethanol is 9.62. For the log Kow of the uncharged molecule, the calculateded value of -1.89 (KOWWIN v1.68; EPISuite v4.11) was used.

Regarding the charged molecule, at pH 7 the log Koc was estimated to be 1.12 (Koc = 13 L/kg) following the method of Franco & Trapp (2008, 2009, 2010). The correction was performed for pH 5, 7, and 8, which represents 98% of the European soils. The value at pH 7 will be used as key value, i.e. for PEC and PNEC calculations.


Referring to the charged molecule at pH 7, the substance is not expected to adsorb to the solid soil phase. 


Henry’s Law Constant (HLC):

The Henry’s Law Constant was calculated by using the bond estimation method of HENRYWIN v3.20 (EPISuite v 4.11) to be 3.17E-04 Pa*m³/mol. The estimation refers to the uncharged molecule. The substance is within the applicability domain of the model.

Based on the calculated data the substance is not expected to evaporate into the atmosphere from the water surface. 


Distribution Modelling:

Based on the results of the Mackay LEVEL I v3.00 calculation, the substance will over time preferentially distribute into the compartment water (100%); the data refer to the uncharged molecule (pKa value: 9.25). However, since the substance will be ionized under environmentally relevant conditions, the distribution into water may still be underestimated.