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Description of key information

The substance was found to rapidly hydrolyse under environmental conditions. The hydrolysis reaction followed pseudo-first order reaction kinetics. It was observed that more rapid hydrolysis occurred under basic conditions. The substance is considered as rapidly degradable and not persistent in the environment.

Key value for chemical safety assessment

Half-life for hydrolysis:
133 h
at the temperature of:
25 °C

Additional information

Since no data for the target substance (L-menthyl acetate, CAS 2623-23-6) are available, the hydrolysis is assessed on the basis of data from one structurally similar substance (stereo isomers). This read-across is in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The target substance L-menthylacetate is a mono-constituent substance. This allows the use of experimental data from a racemic mixture (D- and L-isomers) of menthylacetate for the assessment of the target substance. A detailed justification of the analogue approach is provided in the technical dossier (see IUCLID Section 13).

A valid hydrolysis study in accordance with OECD TG 111 was conducted with the source substance. The results of a preliminary test indicated that further testing is required and the hydrolysis was studied in a main test at pH 4, pH 7 and pH 9 with sample solutions being maintained at 30 °C, 40 °C or 50 °C. It was found that the substance was hydrolysed under all test conditions and that the reaction followed pseudo-first order kinetics. The rate constants for the reaction at 25 °C were estimated by using the Arrhenius relationship and were 0.00517 hr-1 at pH 4, 0.0052 hr-1 at pH 7 and 0.00617 hr-1 at pH 9. This corresponds to half-lives of 137, 133 and 112 hours, respectively.

With a half-life time of < 16 days (max. 6 days) the criteria for rapid degradation according to the CLP/GHS criteria are fulfilled as the degradation products L-Menthol (CAS 2216 -51 -5) and acetic acid (CAS 64-19-7) are readily biodegradable and not classified as hazardous to the aquatic environment.