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EC number: 231-836-6 | CAS number: 7758-19-2
The administration of test substance elevated chloroform levels in the liver and brain but not in the blood.
The formation of chloroform was investigated in two groups of 7 male Sprague-Dawley rats that received 36Cl-labelled sodium chlorite at 100 mg/L in drinking-water for 20 h/day, 7 days/week, for 12 months. After one year, rats were killed and blood collected in heparinized tubes. Tissue samples of liver, kidney, spleen, brain, and testes were homogenized in isotonic sucrose medium. Tissue homogenate or blood sample (3 mL) was extracted by 5 mL pentane. The pentane layer was then separated by centrifugation at 1000 g for 5 min. A gas chromatograph equipped with an electron capture detector was used for the quantitation of chloroform in each sample, with bromodichloromethane being used as the internal standard.
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