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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-02-10 to 2017-02-17
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
470 g/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: SD +/- 30 g/L

Preliminary visual estimation of the water solubility

In a stepwise procedure, increasing volumes of demineralized water were added at room temperature to a defined amount of the test item. After each addition of an amount of water the mixture was treated with ultrasound for 15 minutes and visually checked for any undissolved particles.

Table 2: Results of the preliminary visual estimation of the water solubility

Amount of test item/ mg

Added volume of dist. Water/ mL

Total volume/ mL

Appearance of mixture

88.3

0.1

0.1

Not dissolved

0.4

0.5

dissolved

The preliminary visual experiments showed that the water solubility of the test item is > 10 mg/L. According to the preliminary visual estimation in the main test the water solubility was determined by the flask method.

Flask method
The results of the flask method are given in table 3. After the equilibration time precipitate was observed in the flasks of the experiments excluding in the blank experiment. The water solubility was calculated from the measured and unrounded concentration values and not from the rounded values given in table 3.


Table 3: Water solubility experiments of the test item

Experiment

24 h experiment

48 h experiment

72 h experiment

Blank experiment

(72 h)

Amount of test item/ g

19.14

19.25

19.03

-

Amount of demineralized water/ mL

10

10

10

10

Stirring time at 30 °C/ h

24

48

72

72

Ph at 23 – 24 °C

6.9

7.0

7.0

5.7

Dilution factor

2000

2000

2000

2000

Measured carbon concentration/ mg/L

63.56/ 63.31

61.05/ 60.44

56.62/ 55.22

-/-

Mean carbon concentration/ mg/L

63.4

60.7

55.9

-

Water solubility (1)/ g/L

497

476

438

-

(1) The mean carbon concentration was converted into the water solubility of the test item using the theoretical carbon content of the test item (26 %).

The water solubility of the test item at 20 °C was determined to be 470 g/L (± 30 g/L).

Conclusions:
The water solubility of the test item lithium citrate tetrahydrate was determined to be 470 g/L at 20 °C by the flask method.

Description of key information

The water solubility of the test item lithium citrate tetrahydrate was determined to be 470 g/L at 20 °C by the flask method.

Key value for chemical safety assessment

Water solubility:
470 g/L

Additional information

The water solubility of lithium citrate tetrahydrate was carried out by flask method according to OECD guideline 105 (Siemens, 20160428.03, 2017). A water solubility of 470 g/L was determined for the test substance.