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Description of key information

In an irritation study with rabbits the skin and eye irritation potential of 4-Ethynylphenol was investigated. Based on the hypothesis that 4-Ethylphenol and 4-Ethynylphenol have the same toxicological properties, a read-across is possible.

4-Ethynylphenol caused only a slight skin irritation with very slight to slight erythema. Based on this data the referred classification criteria (Regulation (EC) No 1272/2008) are not met.

In contrast, all animal showed a moderate to serve conjunctival irritation, iritis and corneal opacity 24 h after administration. The severe eye irritation was still present at the end of the observation period seven days after exposure. Therefore, 4-Ethynylphenol is supposed to be highly irritating to eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
March 1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Justification for read-across: see attachment
Reason / purpose for cross-reference:
read-across source
Remarks:
Ethynylphenol
Qualifier:
no guideline followed
Principles of method if other than guideline:
Skin irritation Test (24h exposure on abraded skin) - no further details reported
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no further details stated in the report
Type of coverage:
not specified
Preparation of test site:
abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
24 h
Observation period:
min. 72 h, no further details stated in the report
Number of animals:
4
Details on study design:
Test material was removed with acetone after 24h.
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
72 h
Score:
1
Reversibility:
not specified
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
72 h
Score:
1
Reversibility:
not specified
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
72 h
Score:
2
Reversibility:
not specified
Irritation parameter:
erythema score
Basis:
animal #4
Time point:
72 h
Score:
2
Reversibility:
not specified
Irritation parameter:
edema score
Basis:
animal #1
Time point:
72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
72 h
Score:
1
Reversibility:
not specified
Irritation parameter:
edema score
Basis:
animal #4
Time point:
72 h
Score:
0
Irritant / corrosive response data:
C-979 produced slight dermal irritation. Two of the four animals exhibited very slight (barely perceptable) erythema witnout edema. Two animals exhibited slight erythema with or without edema.
Other effects:
Not reported.
Interpretation of results:
GHS criteria not met
Conclusions:
Under the conditions of this study, the 4-ethynylphenol is considered to be slightly irritating to rabbit skin.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
April 1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Justification for read-across: see attachment
Reason / purpose for cross-reference:
read-across source
Remarks:
Ethynylphenol
Qualifier:
no guideline followed
Principles of method if other than guideline:
Eye Irritation Test (0.1 mL, eyes not rinsed) - no further details reported
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no further details stated in the report
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.1 mL
Duration of treatment / exposure:
not rinsed
Observation period (in vivo):
7 d
Number of animals or in vitro replicates:
4
Details on study design:
no further details stated in the report
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24 h
Score:
2
Reversibility:
not fully reversible within: 7 d
Irritation parameter:
iris score
Basis:
mean
Time point:
24 h
Score:
1.75
Reversibility:
fully reversible within: 7 d
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
mean
Time point:
24 h
Score:
1.25
Reversibility:
fully reversible within: 7 d
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24 h
Score:
3
Reversibility:
not fully reversible within: 7 d
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
7 d
Score:
3.25
Irritation parameter:
chemosis score
Basis:
mean
Time point:
7 d
Score:
0.25
Irritant / corrosive response data:
C-979 produced severe ocular irritation.
All four animals exhibited moderate to severe conjunctival irritation (redness, chemosis, discharge, necrosis), iritis and corneal opacity, stippling and ulceration, at 24 h.
By Day 7, severe irritation was still evident in all animals.
Other effects:
One animal exhibited a constricted pupil at 24 hours; two animals exhibited pannus (neovascularization of the corneal surface) at Day 7; one animal exhibited hair loss around the eye at Day 7.
Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
Under the conditions of this study, the 4-ethynylphenol is considered to be highly irritating to rabbit eyes.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Additional information

Justification for classification or non-classification

Since a read across of 4-Ethylphenol based on 4-Ethynylphenol is possible due to the same toxicological properties,no skin irritation is to be expected. Therefore, the classification criteria are not met for skin irritation.

Based on the read-across of the eye irritation data 4-Ethylphenol is classified as “serve eye irritant, category 1, hazard statement H318 (“Causes serious eye damage”)”.