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Administrative data

Description of key information

Mouse oral LD50 of desipramine is 448 mg/kg/bw.

Rat oral LD50 of desipramine is 375 mg/kg bw.

Rabbit oral LD50 of desipramine is 1000 mg/kg bw.

No data available for acute dermal and inhalation toxicity.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
448 mg/kg bw
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Mouse oral LD50 of desipramine is 448 mg/kg/bw.
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Species:
rabbit
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Rabbit oral LD50 of desipramine is 1000 mg/kg bw.
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
375 mg/kg bw
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Rat oral LD50 of desipramine is 375 mg/kg bw.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
375 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification