Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
ChemID Plus - Desipramine
Bibliographic source:
Bethesda (MD): National Library of Medicine (US).

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Desipramine
EC Number:
200-040-0
EC Name:
Desipramine
Cas Number:
50-47-5
Molecular formula:
C18H22N2
IUPAC Name:
(3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)(methyl)amine
Test material form:
not specified

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
448 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Mouse oral LD50 of desipramine is 448 mg/kg/bw.