Registration Dossier

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

Desipramine has been resulted negative in one Ames test on TA98, 100, 1535, 1537 with and without metabolic activation.

Link to relevant study records
Reference
Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Test concentrations with justification for top dose:
1 - 5000 microg/plate

Test System

AMES SALMONELLA TYPHIMURIUM

 

Strain Indicator

TA98; TA100; TA1535; TA1537

 

Metabolic Activation

NONE and with RAT, LIVER, S-9, AROCLOR 1254

 

Method

STANDARD PLATE

 

Dose

1-5000 UG/PLATE

 

Results

NEGATIVE

Conclusions:
Desipramine has been resulted negative in one Ames test on TA98, 100, 1535, 1537 with and without metabolic activation.

Additional information

Justification for classification or non-classification