Registration Dossier

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
Chemical Carcinogenesis Research Information System - desipramine
Bibliographic source:
Bethesda (MD): National Library of Medicine (US).

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Desipramine
EC Number:
200-040-0
EC Name:
Desipramine
Cas Number:
50-47-5
Molecular formula:
C18H22N2
IUPAC Name:
(3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)(methyl)amine
Test material form:
not specified

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Test concentrations with justification for top dose:
1 - 5000 microg/plate

Results and discussion

Any other information on results incl. tables

Test System

AMES SALMONELLA TYPHIMURIUM

 

Strain Indicator

TA98; TA100; TA1535; TA1537

 

Metabolic Activation

NONE and with RAT, LIVER, S-9, AROCLOR 1254

 

Method

STANDARD PLATE

 

Dose

1-5000 UG/PLATE

 

Results

NEGATIVE

Applicant's summary and conclusion

Conclusions:
Desipramine has been resulted negative in one Ames test on TA98, 100, 1535, 1537 with and without metabolic activation.