Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
explosive properties of explosives
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is an organic substance or mixture containing chemical groups associated with explosive properties, but the exothermic decomposition energy is less than 500 J/g and the onset of exothermic decomposition is below 500°C
Justification for type of information:
The decomposition energy of the substance is less than 500J/g as determined by DSC-Measurement. See further information in the cross-ref.
Cross-reference
Reason / purpose for cross-reference:
data waiving: supporting information
Reference
Endpoint:
thermal stability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 - 20 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)
Version / remarks:
1981
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Test substance thermally stable:
yes
Key result
Operating temp.:
>= 180 - <= 240 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
>= 240 - <= 270 °C
Remarks on result:
other: exothermic effect
Key result
Operating temp.:
>= 290 - <= 350 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
>= 360 - <= 410 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
>= 410 - <= 460 °C
Remarks on result:
other: exothermic effect
Sublimation:
not determined
Transformation products:
not specified

In the temperature range of 180 – 240 °C a first small endothermic effect can be observed, directly followed by an exothermic effect in the temperature range of 240 – 270 °C, with an average decomposition energy of -70 J/g. Two further endothermic effects occurred in the temperature ranges of 290 – 350 °C and 360 – 410 °C, directly followed by a second exothermic effect in the temperature range of 410 – 460 °C, with an average decomposition energy of -60 J/g.

Conclusions:
In a thermal stability test according to the OECD test guideline 113, the test item Alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) showed two exothermic effects in the temperature ranges of 240 – 270 °C and 410 – 460 °C with an overall decomposition energy of approx. -130 J/g.
Executive summary:

In a thermal stability test according to the OECD test guideline 113, the test item Alpha-Ketoglutarate disodium salt (CAS no. 305 -72 -6) showed two exothermic effects in the temperature ranges of 240 – 270 °C and 410 – 460 °C with an overall decomposition energy of approx. -130 J/g.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion