Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
explosive properties of explosives
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties
Justification for type of information:
The decomposition energy of the substance is less than 500J/g as determined by DSC-Measurement. See further information in the cross-ref.
Cross-reference
Reason / purpose for cross-reference:
data waiving: supporting information
Reference
Endpoint:
thermal stability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 - 20 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)
Version / remarks:
1981
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Test substance thermally stable:
yes
Key result
Operating temp.:
>= 180 - <= 240 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
>= 240 - <= 270 °C
Remarks on result:
other: exothermic effect
Key result
Operating temp.:
>= 290 - <= 350 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
>= 360 - <= 410 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
>= 410 - <= 460 °C
Remarks on result:
other: exothermic effect
Sublimation:
not determined
Transformation products:
not specified

In the temperature range of 180 – 240 °C a first small endothermic effect can be observed, directly followed by an exothermic effect in the temperature range of 240 – 270 °C, with an average decomposition energy of -70 J/g. Two further endothermic effects occurred in the temperature ranges of 290 – 350 °C and 360 – 410 °C, directly followed by a second exothermic effect in the temperature range of 410 – 460 °C, with an average decomposition energy of -60 J/g.

Conclusions:
In a thermal stability test according to the OECD test guideline 113, the test item Alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) showed two exothermic effects in the temperature ranges of 240 – 270 °C and 410 – 460 °C with an overall decomposition energy of approx. -130 J/g.
Executive summary:

In a thermal stability test according to the OECD test guideline 113, the test item Alpha-Ketoglutarate disodium salt (CAS no. 305 -72 -6) showed two exothermic effects in the temperature ranges of 240 – 270 °C and 410 – 460 °C with an overall decomposition energy of approx. -130 J/g.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion