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Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 March 2017 - 22 May 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
from 27 July 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium 2-oxoglutarate
EC Number:
206-167-8
EC Name:
Disodium 2-oxoglutarate
Cas Number:
305-72-6
Molecular formula:
C5H6O5.2Na
IUPAC Name:
disodium 2-oxopentanedioate
impurity 1
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
Oxidane
Test material form:
solid: crystalline
Remarks:
Crystalline powder
Details on test material:
Batch No: 14152300
Storage: 15 – 25 °C

Results and discussion

Melting / freezing point
Key result
Atm. press.:
>= 999 - <= 1 019.4 hPa
Decomposition:
yes
Remarks:
The test item showed a decomposition under evaluation of gas starting at approx. 200°C
Decomp. temp.:
ca. 200 °C
Remarks on result:
other:
Remarks:
During the heating phase an endothermic effect was observed in the temperature range of 210 – 260 °C, which cannot be assigned to the melting of the test item.The test item showed a decomposition under evaluation of gas starting at approx. 200°C.

Any other information on results incl. tables

During the heating phase an endothermic effect was observed in the temperature range of 210 – 260 °C, which cannot be assigned to the melting of the test item.The test item showed a decomposition under evaluation of gas starting at approx. 200°C.

No.

Sample weight / mg

Onset of Effect / °C

Range of effect / °C

Weight loss / mg

Atmospheric pressure / hPa

 PN13015

 14.20

243.04 

210 -260(endo) 

8.28 

 1019.4

 PN13047

7.77 

243.57 

210 -260(endo) 

6.66 

 999.0

Applicant's summary and conclusion

Conclusions:
The test item Alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) has no melting point at atmospheric pressure (999 - 1019 hPa) up to the decomposition temperature of approx. 200 °C, as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
Executive summary:

The test item Alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) has no melting point at atmospheric pressure (999 - 1019 hPa) up to the decomposition temperature of approx. 200 °C, as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).