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Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 March 2017 - 22 May 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling Point)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium 2-oxoglutarate
EC Number:
206-167-8
EC Name:
Disodium 2-oxoglutarate
Cas Number:
305-72-6
Molecular formula:
C5H6O5.2Na
IUPAC Name:
disodium 2-oxopentanedioate
impurity 1
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
Oxidane
Test material form:
solid: crystalline
Remarks:
Crystalline powder
Details on test material:
Batch No: 14152300
Storage: 15 – 25 °C

Results and discussion

Boiling point
Key result
Atm. press.:
>= 999 - <= 1 019.4 hPa
Decomposition:
yes
Remarks:
the test item showed decomposition under evaluation of gas starting at ca. 200 °C.
Decomp. temp.:
ca. 200 °C
Remarks on result:
other:
Remarks:
no boiling of the test item could be detected up to 500°C under atmospheric pressure

Any other information on results incl. tables

During the heating phase an endothermic effect was observed in the temperature range of 210 – 260 °C, which cannot be assigned to the melting of the test item. The test item showed a decomposition under evaluation of gas starting at approx. 200°C.

No further evaluable thermal effects were observed up to the test end temperature of 500 °C. Thus, no boiling of the test item could be detected up to 500 °C under atmospheric pressure.

 Run  Sample weight (mg)  Onset of effect (°C)  Range of effect (°C)  Weight loss (mg)  Atmospheric pressure (hPa)
 1  14.20  243.04  210 -260 (endo)  8.28  1019.4
 2  7.77  243.57  210 -260 (endo)  6.66  999.0

Applicant's summary and conclusion

Conclusions:
The test item Alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) has no boiling point up to the decomposition of temperature of approx. 200°C at atmospheric pressure (999 - 1019 hPa) as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline 103 (1995).
Executive summary:

The test item Alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) has no boiling point up to the decomposition of temperature of approx. 200°C at atmospheric pressure (999 - 1019 hPa) as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline 103 (1995).