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Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Version / remarks:
1981
Deviations:
no
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
2009
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium 2-oxoglutarate
EC Number:
206-167-8
EC Name:
Disodium 2-oxoglutarate
Cas Number:
305-72-6
Molecular formula:
C5H6O5.2Na
IUPAC Name:
disodium 2-oxopentanedioate
impurity 1
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
Oxidane
Test material form:
solid: crystalline
Remarks:
Crystalline powder
Details on test material:
Batch No: 14152300
Storage: 15 – 25 °C
Specific details on test material used for the study:
Since the test item contains no lager particles, sieving < 2000 µm was not necessary and the test item was used as delivered.

Results and discussion

Particle sizeopen allclose all
Key result
Percentile:
D10
Mean:
1.3 µm
St. dev.:
0
Remarks on result:
other: mean of two test series (1.3 µm; 1.3 µm)
Key result
Percentile:
D50
Mean:
105.7 µm
St. dev.:
0.93
Remarks on result:
other: mean of two test series (106.6 µm; 104.8 µm)
Key result
Percentile:
D90
Mean:
581.3 µm
St. dev.:
4.87
Remarks on result:
other: mean of two test series (576.4 µm; 581.3 µm)

Any other information on results incl. tables

Light microscopy

At all three magnifications (5x, 20x, 50x) only agglomerates can be observed. 

Particle size distribution

The test item shows a bimodal particle size distribution with two peaks at approx. 2.5 µm and 400 µm.

Test series 1:

 Percentile  Particle size (µm)  Standard deviation
 D10  1.3  0.02
 D50  106.6  7.13
 D90  576.4 31.9

Test series 2:

 Percentile  Particle size (µm)  Standard deviation
 D10  1.3  0.02
 D50  104.8  7.21
 D90  581.3 41.4

Applicant's summary and conclusion

Conclusions:
The test item a-Ketoglutarate disodium salt (CAS no. 305-72-6) has a median particle size D50 = 105.7 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).
Executive summary:

The test item a-Ketoglutarate disodium salt (CAS no. 305-72-6) has a median particle size D50 = 105.7 µm, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981), ISO 13320 (2009) and EPA OCSPP Guideline OPPTS 830.7520 (1996).