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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November / December 1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
Test animal, application of the test chemical, dose level
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-lauroyloxyethyltrimethylammonium chloride
EC Number:
246-745-7
EC Name:
2-lauroyloxyethyltrimethylammonium chloride
Cas Number:
25234-60-0
Molecular formula:
C17H36NO2.Cl
IUPAC Name:
[2-(dodecanoyloxy)ethyl]trimethylazanium chloride

Test animals

Species:
guinea pig
Strain:
not specified
Details on test animals or test system and environmental conditions:
Housing and feeding conditions:
The temperature of the experimental animal room was 20°C. The relative humidity was 50%. Lighting was artificial, the sequence was 12 hours light, 12 hours dark. Food and water was provided at discretion.

Test system

Type of coverage:
open
Preparation of test site:
shaved
Vehicle:
other: vaseline
Controls:
not specified
Amount / concentration applied:
200 ppm
Duration of treatment / exposure:
7 d
Observation period:
daily
Number of animals:
12

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
After daily application of the test substance 2-lauroyloxyethyltrimethylammonium chloride in vaseline no skin irritation could be observed, after one week. The test substance can be stated as non-irritating.