Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November / December 1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
Test animal, application of the test chemical, dose level
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-lauroyloxyethyltrimethylammonium chloride
EC Number:
246-745-7
EC Name:
2-lauroyloxyethyltrimethylammonium chloride
Cas Number:
25234-60-0
Molecular formula:
C17H36NO2.Cl
IUPAC Name:
[2-(dodecanoyloxy)ethyl]trimethylazanium chloride

Test animals

Species:
guinea pig
Strain:
not specified
Details on test animals or test system and environmental conditions:
Housing and feeding conditions:
The temperature of the experimental animal room was 20°C. The relative humidity was 50%. Lighting was artificial, the sequence was 12 hours light, 12 hours dark. Food and water was provided at discretion.

Test system

Type of coverage:
open
Preparation of test site:
shaved
Vehicle:
other: vaseline
Controls:
not specified
Amount / concentration applied:
200 ppm
Duration of treatment / exposure:
7 d
Observation period:
daily
Number of animals:
12

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal: all
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
After daily application of the test substance 2-lauroyloxyethyltrimethylammonium chloride in vaseline no skin irritation could be observed, after one week. The test substance can be stated as non-irritating.