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Short-term toxicity to fish

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Description of key information

TLm > 1000 mg/l

Key value for chemical safety assessment

Additional information

37 kinds of dyes which contained nitrogen were subjected to TLm test by use of Himedaka ( Oryzias latipes), and the results were compared with their partition coeffieients between n-octanol and water. Concerning organic nitrogen compounds, such good correlation was observed among them that the larger the partition coeffieient was, the smaller was the TLm value. Their acute toxicity to fish was supposed to be revealed after their passage through cell membrane of fish to be accumulated in the body. As far as coal tar dyes and dyestuffs were concerned, there was a correlation between partition coefricient and TLm value.

The TLm value calculated for the test substance was > 1000mg/l.