2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as- 1. and 2.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (as cited in study report): 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated- Substance type: Organic- smiles : Cc1ccccc1N=Nc2ccc(c(C)c2)N=Nc3c4ccc(C(C)c5ccccc5)cc4cc(C(C)c6ccccc6)c3O- Molecular wt. : 588.76

Radiolabelling:

not specified

Analytical monitoring:

not specified

Estimation method (if used):

1. Not specified2. Structure estimation method

Temp.:

50 °C

Remarks:

1) Study was performed at different pH range, i.e, at pH 4, 7 and 9.

Remarks:

2) No details available

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

pH:

4

Temp.:

50 °C

Remarks on result:

other: at pH range 4, 5 and 7, respectively. Half-life value of test chemical is not known, but chemical is stable i.e not hydrolysed at pH 4, 7 and 9, respectively.

pH:

7

DT50:

6 yr

Type:

second order

Remarks on result:

other: Hydrolysis rate constant is 0.038 L/mol-sec.

pH:

8

DT50:

211 d

Type:

second order

Remarks on result:

other: Hydrolysis rate constant is 0.038 L/mol-sec.

Details on results:

1. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively and at a temperature of 50⁰C. 2. No data available

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated can be expected to be 6 yrs and 211 days at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.038 L/mol-sec and was reported to be hydrolytically stable at pH 4, 7 and 9, respectively & at a temperature of 50⁰C, respectively.Thus, based on this half-life value, it can be concluded that the test chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated is not hydrolysable.

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated (CAS no. 85203 -90 -3).The studies are as mentioned below:

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Although, half-life value of test chemical is not known, but chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively and at a temperature of 50⁰C. Based on this, it is concluded that test chemical is not hydrolysable.

In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.038 L/mol-sec with a corresponding half-lives of 6 yrs and 211 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that test chemical is not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated can be expected to be 6 yrs and 211 days at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.038 L/mol-sec and was reported to be hydrolytically stable at pH 4, 7 and 9, respectively & at a temperature of 50⁰C, respectively.Thus, based on this half-life value, it can be concluded that the test chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated is not hydrolysable.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated can be expected to be 6 yrs and 211 days at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.038 L/mol-sec and was reported to be hydrolytically stable at pH 4, 7 and 9, respectively & at a temperature of 50⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated is not hydrolysable.

Key value for chemical safety assessment

Half-life for hydrolysis:

6 yr

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated (CAS no. 85203 -90 -3).The studies are as mentioned below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Although, half-life value of test chemical is not known, but chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively and at a temperature of 50⁰C. Based on this, it is concluded that test chemical is not hydrolysable.

 

In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.038 L/mol-sec with a corresponding half-lives of 6 yrs and 211 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that test chemical is not hydrolysable.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated can be expected to be 6 yrs and 211 days at pH 7 and 8, respectively with a second order hydrolysis rate constant of 0.038 L/mol-sec and was reported to be hydrolytically stable at pH 4, 7 and 9, respectively & at a temperature of 50⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated is not hydrolysable.