2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated

Endpoint summary

Description of key information

Bioaccumulation:aquatic/sediment:

BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical 2-Naphthalenol, 1-[[2-methyl- 4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated (CAS No. 85203 -90 -3). The bioconcentration factor (BCF) of 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo]phenyl] azo]-, ar-styrenated was estimated to be 10 L/kg whole body w.w (at 25 deg C) which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated is not expected to bioaccumulate in the food chain.

Additional information

Bioaccumulation:aquatic/sediment:

One predicted data study for the target compound 2-Naphthalenol, 1-[[2-methyl- 4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated (CAS No. 85203 -90 -3)and supporting weight of evidence study for its read across chemical were reviewed for the bioaccumulation end point which are summarized as below:

In first weight of evidence study the BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical 2-Naphthalenol, 1-[[2-methyl- 4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated (CAS No. 85203 -90 -3). The bioconcentration factor (BCF) of 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo]phenyl] azo]-, ar-styrenated was estimated to be 10 L/kg whole body w.w (at 25 deg C) which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated is not expected to bioaccumulate in the food chain.

Next weight of evidence study was done from authoritative databasein this study the Bioaccumulation experiment was conducted for 6 weeks for determination the bioconcentration factor (BCF) of test chemical chemical on test organism Cyprinus carpio. 

The vehicle used in the study was HCO-40, Crystal sugar, Concentration of vehicle: 1st Concentration area: HCO-40 14 ppm(w/v), Crystal sugar 14 ppm(w/v), 2nd Concentration area: HCO-40 1.4 ppm(w/v) Crystal sugar 1.4 ppm(w/v)

Recovery ratio: Test water : 1st concentration area : 96.1 %, 2nd concentration area : 95.4 %, Fish : 79.8 %, - Limit of detection : Fish : 0.25 ppm

The Nominal concentrations used in the study was 1st Concentration area: 0.7 mg/L(w/v), 2nd Concentration area: 0.07 mg/L (w/v)and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h>= 420 ppm(w/v).

 Thus according to static Fish test the bioconcentration factor (BCF) for test  chemical was determined according static fish test. The BCF value was observed to be 0.9 – 1.8 L/kg at dose concentration 0.7 mg/L and 8.5 - 15 L/kg at dose concentration 0.07 mg/L on test organism Cyprinus carpio during 6 weeks period. Therefore it is concluded that test chemical is non bioaccumulative.

Last weight of evidence study was done from another authoritative database for test chemical chemical in this study the ionic character of test chemical chemical suggests the potential for bioconcentration in aquatic organisms is expected to be low.

On the basis of above results for target chemical 2-Naphthalenol, 1-[[2-methyl- 4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated (CAS No. 85203 -90 -3) (from EPI suite 2017) and for its read across chemicals it can be concluded that the BCF value of test substance 2-Naphthalenol, 1-[[2-methyl- 4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated (CAS No. 85203 -90 -3)ranges from 0.0 to 15 L/Kg dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 2-Naphthalenol, 1-[[2-methyl- 4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenatedis expected to be nonbioaccumulative in the food chain.