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Description of key information

There are no studies available in which the toxicokinetic properties of the registration substance were investigated.

 

Hordaphos CC MIN is a light yellow liquid, which is reaction mass of methyl dihydrogen phosphate and diisopropyl hydrogen phosphate and orthophosphoric acid and isopropyl dihydrogen phosphate. The substance is miscible with water at room temperature in any ratio (see chapter 4.8). The octanol water partition coefficient (Log Pow) for Hordaphos CC MIN was calculated using EPI Suite. It can only be estimated as average of its different organic components which lay between -0.71 and 1.16 (see chapter 4.7). Due to the very high water solubility in combination with its organic components a general potential of bioaccumulation might be excluded.

 

Absorption

With reference to the considerable solubility in water the absorption of the registration substance is considered to be readily dissolved into the gastrointestinal tract (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, Table R.7.12-1, p. 152). However, if amounts of the substance are dissolved in aqueous solutions it will dissociate into its ionic compounds (hydrolysis of esters). Ionisation does not contribute to a readily diffusion across biological membranes (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 150). Based on these properties, absorption of Hordaphos CC MIN cannot be excluded. However, no severe systemic effects were observed in the course of acute oral toxicity studies in rats or of an OECD 422 study with its structural analogue, Hordaphos CC MIS (NOAEL 1000 mg/kg bw/d).

Distribution

The registration substance is water soluble. Therefore, it will diffuse through aqueous channels and pores. However, “the rate at which very hydrophilic molecules diffuse across membranes could limit their distribution” (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, pp. 159-160).

 

Metabolism

Taking into account the water solubility an uptake of amounts of this substance cannot be excluded. Studies on genotoxicity performed with the structual analogue, Hordaphos CC MIS, or its components, isopropanol and phosphoric acid (Ames-Test; chromosome aberration test and HPRT test) were negative, i.e. there is no indication of a reactivity of the substance under the test conditions. With reference to its chemical composition and structure metabolism might lead to the hydrolysis of the ester binding. This conclusion is supported by the water solubility.

Excretion

With reference to the solubility the urinary excretion might be considered as the most favorable excretion route (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 161).

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information