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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Similar to OECD 202, non GLP, key study, validity 2:

Under the test conditions, the 48 h EC50 value estimated was > 180 mg/L and < 320 mg/L.

Key value for chemical safety assessment

Additional information

A study was performed to assess the acute toxicity of the test item to the freshwater invertebrateDaphnia magnasimilarly to OECD Guideline 202.

Daphnids were exposed to the test item for 48 hours at 2 series of concentrations: the first one with3.2, 5.6, 10, 32, 56, 100, 180 and 320 mg/Land the second one with 0.32, 0.56, 1.0, 1.8, 3.2 mg/L. The second series (with lower concentrations) was perfomed because the condition of Daphnia at 3.2 mg/L was worse than that of the Daphnia in DSW without Akypoquat.

In both cases, the no-treatment control daphnids were exposed to dilution water only. There were two replicates per treatment with 25 daphnids per replicate, which provided a total of 50 daphnids per treatment and control group at test initiation. The test temperature was 18 °C.

After 24 h the condition of theDaphniawas assessed and the dead animals counted and removed. After 48 h the condition of theDaphniawas again assessed and the dead and living animals counted; the pH and oxygen concentration of all test solutions were measured. 

 

Under the test conditions, no immobilisation occurred up to 180 mg/L. The 48 h EC50 value estimated was > 180 mg/L and < 320 mg/L. As this is far greater than the CMC this may be a physical effect caused by insoluble material.