Magnesium methanolate

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

short-term repeated dose toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Test procedure in accordance with accepted standard methods, insufficiently documented, limitations in tissue examination.

Data source

Reference

Reference Type:

publication

Title:

Subchronic inhalation toxicity of methanol.

Author:

Andrews, L.S., Clary, J.J., Terrill, J.B., Bolte, H.F.

Year:

1987

Bibliographic source:

J. Toxicol. Envir. Health 20, 117-124

Materials and methods

Principles of method if other than guideline:

Investigation of the effects of subacute exposure to methanol vapours in monkeys with histopathological examinations lacking brain and neural tissue.

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methanol

EC Number:

200-659-6

EC Name:

Methanol

Cas Number:

67-56-1

Molecular formula:

CH4O

IUPAC Name:

methanol

Details on test material:

- Name of test material (as cited in study report): methanol
- Analytical purity: 99.85 %
- Other: Source: Celanese Corp., N.Y., no further data

Test animals

Species:

monkey

Strain:

Macaca fascicularis

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Remarks on MMAD:

MMAD / GSD: not applicable

Analytical verification of doses or concentrations:

yes

Details on analytical verification of doses or concentrations:

Chamber methanol concentration measured regularly by IR.

Duration of treatment / exposure:

4 weeks

Frequency of treatment:

6 h/d, 5 d/wk

Doses / concentrations

Remarks:

Doses / Concentrations:
0.66, 2.65, 6.63 mg/L (corresponding to 500, 2000, 5000 ppm)
Basis:
analytical conc.

No. of animals per sex per dose:

3

Control animals:

yes, concurrent no treatment

Positive control:

not applicable

Examinations

Observations and examinations performed and frequency:

CAGE SIDE OBSERVATIONS: Yes
- Time schedule: no data

OPHTHALMOSCOPIC EXAMINATION: Yes
- Time schedule for examinations: at the end of exposure
- Dose groups that were examined: no data

Sacrifice and pathology:

GROSS PATHOLOGY: No data
HISTOPATHOLOGY: Yes (ophthalmoscopy)

Results and discussion

Results of examinations

Details on results:

CLINICAL SIGNS AND MORTALITY
No clinical signs of intoxication.

OPHTHALMOSCOPIC EXAMINATION
No methanol-related abnormalities.

HISTOPATHOLOGY: NON-NEOPLASTIC
No methanol-related abnormalities.

Effect levels

Dose descriptor:

NOAEC

Effect level:

6.63 mg/L air

Sex:

male/female

Basis for effect level:

other: clinical signs, histopathology, ophthalmoscopy

Target system / organ toxicity

Critical effects observed:

not specified