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Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw materials monographs: Anisyl alcohol
Author:
D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology, Volume 12, Issues 7–8, December 1974, Page 825.
Reference Type:
other: authoritative database
Title:
Acute dermal toxicity study of 4-Methoxybenzyl alcohol (CAS no: 105-13-5) in Rabbit.
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
IFA GESTIS, GESTIS SUBSTANCE Database, 2017.
Reference Type:
publication
Title:
Fragrance material review on anisyl alcohol
Author:
J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api
Year:
2012
Bibliographic source:
Food and Chemical Toxicology 50 (2012) S134–S139
Reference Type:
secondary source
Title:
Acute Dermal Toxicity of 4-Methoxybenzyl alcohol in Rabbit.
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance data base), 2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute Dermal toxicity study of 4-methoxybenzyl alcohol (105-13-5) in rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methoxybenzyl alcohol
EC Number:
203-273-6
EC Name:
4-methoxybenzyl alcohol
Cas Number:
105-13-5
Molecular formula:
C8-H10-O2
IUPAC Name:
(4-methoxyphenyl)methanol
Details on test material:
Name: 4-methoxybenzyl alcohol
InChI: 1S/C8H10O2/c1-10-8-4-2-7(6-9)3-5-8/h2-5,9H,6H2,1H3
Smiles:c1(ccc(OC)cc1)CO
- Molecular formula (if other than submission substance):C8H10O2
- Molecular weight (if other than submission substance):138.165 g/mol
- Substance type:Organic
Specific details on test material used for the study:
Name: 4-methoxybenzyl alcohol
InChI: 1S/C8H10O2/c1-10-8-4-2-7(6-9)3-5-8/h2-5,9H,6H2,1H3
Smiles:c1(ccc(OC)cc1)CO
- Molecular formula (if other than submission substance):C8H10O2
- Molecular weight (if other than submission substance):138.165 g/mol
- Substance type:Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
1250, 2500, and 5000 mg/kg
No. of animals per sex per dose:
Groups of 4 rabbits/dose
Control animals:
not specified
Details on study design:
- Other examinations performed: Animals were observed for clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 000 mg/kg bw
Based on:
test mat.
95% CL:
1 940 - 4 060
Remarks on result:
other: 50% mortality was observed
Mortality:
Mortalities included 1 rabbit from the 2500 g/kg group on day 1, and all 4 rabbits from the 5000 mg/kg group by day 6.
Clinical signs:
other: Clinical signs of toxicity included loss of coordination and muscle tone in 2 animals at 5000 mg/kg and 1 animal at 2500 mg/kg. Slight to moderate erythema and edema was also observed in all animals.
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be 3000 mg/kg with 95% confidential limit of 1940-4060 mg/kg bw, when rabbit was treated with 4-methoxybenzyl alcohol (105-13-5) by dermal application.
Executive summary:

Acute dermal toxicity study of 4-methoxybenzyl alcohol (105-13-5) was conducted in rabbit at the concentration of 1250, 2500, and 5000 mg/kg bw. Animals were observed for clinical signs.Mortalities included 1 rabbit from the 2500 g/kg group on day 1, and all 4 rabbits from the 5000 mg/kg group by day 6.Clinical signs of toxicity included loss of coordination and muscle tone in 2 animals at 5000 mg/kg and 1 animal at 2500 mg/kg. Slight to moderate erythema and edema was also observed in all animals. Therefore, LD50 was considered to be 3000 mg/kg with 95% confidential limit of 1940-4060 mg/kg bw, when rabbit was treated with 4-methoxybenzyl alcohol by dermal application.