4-(2-aminoethyl)phenol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from Publication.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Fragrance raw materials monographs: Anisyl alcohol

Author:

D. L. J. Opdyke

Year:

1974

Bibliographic source:

Food and Cosmetics Toxicology, Volume 12, Issues 7–8, December 1974, Page 825.

Reference 2

Reference Type:

other: authoritative database

Title:

Acute dermal toxicity study of 4-Methoxybenzyl alcohol (CAS no: 105-13-5) in Rabbit.

Author:

IFA GESTIS

Year:

2017

Bibliographic source:

IFA GESTIS, GESTIS SUBSTANCE Database, 2017.

Reference 3

Reference Type:

publication

Title:

Fragrance material review on anisyl alcohol

Author:

J. Scognamiglio, L. Jones, C.S. Letizia, A.M. Api

Year:

2012

Bibliographic source:

Food and Chemical Toxicology 50 (2012) S134–S139

Reference 4

Reference Type:

secondary source

Title:

Acute Dermal Toxicity of 4-Methoxybenzyl alcohol in Rabbit.

Author:

RTECS

Year:

2018

Bibliographic source:

RTECS (registry of toxic effect of chemical substance data base), 2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as metioned below

Principles of method if other than guideline:

Acute Dermal toxicity study of 4-methoxybenzyl alcohol (105-13-5) in rabbit.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-methoxybenzyl alcohol

EC Number:

203-273-6

EC Name:

4-methoxybenzyl alcohol

Cas Number:

105-13-5

Molecular formula:

C8-H10-O2

IUPAC Name:

(4-methoxyphenyl)methanol

Details on test material:

Name: 4-methoxybenzyl alcohol
InChI: 1S/C8H10O2/c1-10-8-4-2-7(6-9)3-5-8/h2-5,9H,6H2,1H3
Smiles:c1(ccc(OC)cc1)CO
- Molecular formula (if other than submission substance):C8H10O2
- Molecular weight (if other than submission substance):138.165 g/mol
- Substance type:Organic

Specific details on test material used for the study:

Name: 4-methoxybenzyl alcohol
InChI: 1S/C8H10O2/c1-10-8-4-2-7(6-9)3-5-8/h2-5,9H,6H2,1H3
Smiles:c1(ccc(OC)cc1)CO
- Molecular formula (if other than submission substance):C8H10O2
- Molecular weight (if other than submission substance):138.165 g/mol
- Substance type:Organic

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Type of coverage:

other: Dermal

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

not specified

Duration of exposure:

not specified

Doses:

1250, 2500, and 5000 mg/kg

No. of animals per sex per dose:

Groups of 4 rabbits/dose

Control animals:

not specified

Details on study design:

- Other examinations performed: Animals were observed for clinical signs.

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

3 000 mg/kg bw

Based on:

test mat.

95% CL:

1 940 - 4 060

Remarks on result:

other: 50% mortality was observed

Mortality:

Mortalities included 1 rabbit from the 2500 g/kg group on day 1, and all 4 rabbits from the 5000 mg/kg group by day 6.

Clinical signs:

other: Clinical signs of toxicity included loss of coordination and muscle tone in 2 animals at 5000 mg/kg and 1 animal at 2500 mg/kg. Slight to moderate erythema and edema was also observed in all animals.

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

LD50 was considered to be 3000 mg/kg with 95% confidential limit of 1940-4060 mg/kg bw, when rabbit was treated with 4-methoxybenzyl alcohol (105-13-5) by dermal application.

Executive summary:

Acute dermal toxicity study of 4-methoxybenzyl alcohol (105-13-5) was conducted in rabbit at the concentration of 1250, 2500, and 5000 mg/kg bw. Animals were observed for clinical signs.Mortalities included 1 rabbit from the 2500 g/kg group on day 1, and all 4 rabbits from the 5000 mg/kg group by day 6.Clinical signs of toxicity included loss of coordination and muscle tone in 2 animals at 5000 mg/kg and 1 animal at 2500 mg/kg. Slight to moderate erythema and edema was also observed in all animals. Therefore, LD50 was considered to be 3000 mg/kg with 95% confidential limit of 1940-4060 mg/kg bw, when rabbit was treated with 4-methoxybenzyl alcohol by dermal application.