Registration Dossier
Registration Dossier
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EC number: 222-824-1 | CAS number: 3623-51-6
Endpoint summary
Administrative data
Description of key information
Additional information
There are no data available on the biodegradation ofthe target substance. In order to fulfil the standard information requirements, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from structurally related substances was conducted.
In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.”
Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity. Please refer to IUCLID section 13 for a detailed justification of the category approach.
The target substance is a racemic mixture of D-, and L-menthol.The source substances L-menthol (CAS 2216-51-5), D-menthol (CAS 15356-60-2) and D/L-menthol (CAS 1490-04-6) are stereo-isomers of the target substance.This allows the use of experimental data from D-menthol and L-menthol for the assessment of the target substance.
Based on the results from two experimental studies according to
OECD 301D it can be concluded that the target substance is readily
biodegradable according to the OECD criteria (79 - 92% biodegradation
after 28 d based on O2 consumption). The degradation via abiotic
hydrolysis is not considered to be a relevant degradation pathway in the
environment, since the target substance has no functional chemical
groups allowing hydrolysis under environmental conditions.
Considering the water solubility of 231 mg/L and the low potential for
adsorption to organic soil and sediment particles (log Koc: 1.94 - 2.28
L/kg, mean: 2.11, KOCWIN v2.00), the main compartment for environmental
distribution is expected to be the surface water. Evaporation into air
and the transport through the atmospheric compartment is not considered
to be relevant based on the Henry’s Law Constant of 1.54 - 2.6 Pa
m³/mole (HenryWin v3.20) and a vapour pressure of 3.6 Pa at 25 °C.
The potential for bioaccumulation was assessed based on an experimental study according to OECD 305C performed with the source substance D/L-menthol (CAS 1490-04-6). This study resulted in a BCF of ≤ 15 L/kg indicating a low potential for bioaccumulation. Thus, the substance is not considered to meet the B/vB criterion to classify the substance as bioaccumulative and very bioaccumulative.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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