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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
(no details on test animals and environmental conditions were given

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicity and Skin Corrosion Data for Some Organic and Inorganic Compounds and Aqueous Solutions
Author:
Vernot, E.H. et al.
Year:
1977
Bibliographic source:
Toxicol Appl Pharmacol. 42:417-23.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single oral dose toxicity was usually determined by the method of Smyth et al. (1962) in which the LD50 and its 95% confidence limits are estimated by the moving average technique (Thompson, 1947; Weil, 1952). Occasionally enough data were obtained to use the probit method (Finney, 197 1) for calculation.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Oxalic acid
EC Number:
205-634-3
EC Name:
Oxalic acid
Cas Number:
144-62-7
Molecular formula:
C2H2O4
IUPAC Name:
oxalic acid
Test material form:
solid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200 - 300 g
- Diet: Purina Formulab Chow 5008

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
7.5 mL/kg bw
Based on:
test mat.
Remarks:
5% (w/v) in aqueous solution
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
9.5 mL/kg bw
Based on:
test mat.
Remarks:
5% (w/v) in aqueous solution
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
375 mg/kg bw
Based on:
test mat.
Remarks:
100% by calculation
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
475 mg/kg bw
Based on:
test mat.
Remarks:
100% by calculation

Applicant's summary and conclusion

Interpretation of results:
other: Category 4 based on CLP/EU GHS criteria, according to Regulation (EC) No 1272/2008
Conclusions:
CLP: Acute Oral 4, H302 (Annex VI harmonized classification)

The available data on acute toxicity (oral) are in consistency with the harmonized classification according to Regulation (EC) 1272/2008, Annex VI.