Registration Dossier
Registration Dossier
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EC number: 204-578-7 | CAS number: 122-84-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance Raw Material Monographs - p-methoxyphenylacetone
- Author:
- Edited by D.L.J. Opdyke
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology, Volume 17, Supplement, December 1979, Page 857
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To evaluate skin irritation potential of 4-methoxyphenylacetone on human subjects.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-methoxyphenylacetone
- EC Number:
- 204-578-7
- EC Name:
- 4-methoxyphenylacetone
- Cas Number:
- 122-84-9
- Molecular formula:
- C10H12O2
- IUPAC Name:
- 1-(4-methoxyphenyl)propan-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material: 4-methoxyphenylacetone
- IUPAC name: 1-(4-methoxyphenyl)acetone
- Molecular formula: C10H12O2
- Molecular weight: 164.203 g/mole
- Smiles : c1(ccc(OC)cc1)CC(C)=O
- Inchl: 1S/C10H12O2/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless, oily liquid
Constituent 1
- Specific details on test material used for the study:
- IUPAC name: p- methoxyphenylacetone
Common name:1-(p-Methoxyphenyl)-2-propanone
Molecular formula:C10H12O2
Molecular weight :164.203 g/mol
Substance type:organic
InChI:1S/C10H12O2/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3
SMILES Notation: c1(ccc(OC)cc1)CC(C)=O
Physical State: Liquid
Test animals
- Species:
- other: Human
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- 4% in petrolatum
- Duration of treatment / exposure:
- 48 hrs
- Observation period:
- 48 hrs
- Number of animals:
- no data available
- Details on study design:
- no data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No indication of skin reaction observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- 4-methoxyphenylacetone was not irritating to human skin after 48 hours exposure.
- Executive summary:
A skin irritation study was performed on humans to assess the irritation potential of 4-methoxyphenylacetone. 4-methoxyphenylacetone 4% in petrolatum was tested on human volunteers in a 48 hours closed patch test. The volunteers were observed for signs of irritation. 4-methoxyphenylacetone was not irritating to human skin after 48 hours exposure.
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