4-methoxyphenylacetone

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journals

Data source

Reference

Reference Type:

publication

Title:

Fragrance Raw Material Monographs - p-methoxyphenylacetone

Author:

Edited by D.L.J. Opdyke

Year:

1979

Bibliographic source:

Food and Cosmetics Toxicology, Volume 17, Supplement, December 1979, Page 857

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To evaluate skin irritation potential of 4-methoxyphenylacetone on human subjects.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

4-methoxyphenylacetone

EC Number:

204-578-7

EC Name:

4-methoxyphenylacetone

Cas Number:

122-84-9

Molecular formula:

C10H12O2

IUPAC Name:

1-(4-methoxyphenyl)propan-2-one

Test material form:

liquid

Details on test material:

- Name of test material: 4-methoxyphenylacetone
- IUPAC name: 1-(4-methoxyphenyl)acetone
- Molecular formula: C10H12O2
- Molecular weight: 164.203 g/mole
- Smiles : c1(ccc(OC)cc1)CC(C)=O
- Inchl: 1S/C10H12O2/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless, oily liquid

Specific details on test material used for the study:

IUPAC name: p- methoxyphenylacetone
Common name:1-(p-Methoxyphenyl)-2-propanone
Molecular formula:C10H12O2
Molecular weight :164.203 g/mol
Substance type:organic
InChI:1S/C10H12O2/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3
SMILES Notation: c1(ccc(OC)cc1)CC(C)=O
Physical State: Liquid

Test animals

Species:

other: Human

Strain:

not specified

Details on test animals or test system and environmental conditions:

No data available

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

other: petrolatum

Controls:

not specified

Amount / concentration applied:

4% in petrolatum

Duration of treatment / exposure:

48 hrs

Observation period:

48 hrs

Number of animals:

no data available

Details on study design:

no data available

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

48 h

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No indication of skin reaction observed

Applicant's summary and conclusion

Interpretation of results:

other: not irritating

Conclusions:

4-methoxyphenylacetone was not irritating to human skin after 48 hours exposure.

Executive summary:

A skin irritation study was performed on humans to assess the irritation potential of 4-methoxyphenylacetone. 4-methoxyphenylacetone 4% in petrolatum was tested on human volunteers in a 48 hours closed patch test. The volunteers were observed for signs of irritation. 4-methoxyphenylacetone was not irritating to human skin after 48 hours exposure.