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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Fragrance Raw Material Monographs - p-methoxyphenylacetone
Author:
Edited by D.L.J. Opdyke
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology, Volume 17, Supplement, December 1979, Page 857

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate skin irritation potential of 4-methoxyphenylacetone on human subjects.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methoxyphenylacetone
EC Number:
204-578-7
EC Name:
4-methoxyphenylacetone
Cas Number:
122-84-9
Molecular formula:
C10H12O2
IUPAC Name:
1-(4-methoxyphenyl)propan-2-one
Test material form:
liquid
Details on test material:
- Name of test material: 4-methoxyphenylacetone
- IUPAC name: 1-(4-methoxyphenyl)acetone
- Molecular formula: C10H12O2
- Molecular weight: 164.203 g/mole
- Smiles : c1(ccc(OC)cc1)CC(C)=O
- Inchl: 1S/C10H12O2/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless, oily liquid
Specific details on test material used for the study:
IUPAC name: p- methoxyphenylacetone
Common name:1-(p-Methoxyphenyl)-2-propanone
Molecular formula:C10H12O2
Molecular weight :164.203 g/mol
Substance type:organic
InChI:1S/C10H12O2/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3
SMILES Notation: c1(ccc(OC)cc1)CC(C)=O
Physical State: Liquid

Test animals

Species:
other: Human
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: petrolatum
Controls:
not specified
Amount / concentration applied:
4% in petrolatum
Duration of treatment / exposure:
48 hrs
Observation period:
48 hrs
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No indication of skin reaction observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
4-methoxyphenylacetone was not irritating to human skin after 48 hours exposure.
Executive summary:

A skin irritation study was performed on humans to assess the irritation potential of 4-methoxyphenylacetone. 4-methoxyphenylacetone 4% in petrolatum was tested on human volunteers in a 48 hours closed patch test. The volunteers were observed for signs of irritation. 4-methoxyphenylacetone was not irritating to human skin after 48 hours exposure.