Registration Dossier
Registration Dossier
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EC number: 216-823-5 | CAS number: 1675-54-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was not conducted under GLP or guideline, but uses generally accepted, scientifically valid methods.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Exposure was conducted at saturated atmosphere.
- GLP compliance:
- no
- Test type:
- other: Limit test in saturated atmosphere
- Limit test:
- yes
Test material
- Reference substance name:
- 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
- EC Number:
- 500-033-5
- EC Name:
- 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
- Cas Number:
- 25068-38-6
- Molecular formula:
- (C15 H16 O2 . C3 H5 Cl O)x
- IUPAC Name:
- 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
- Reference substance name:
- 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
- EC Number:
- 216-823-5
- EC Name:
- 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
- Cas Number:
- 1675-54-3
- Molecular formula:
- C21H24O4
- IUPAC Name:
- 2,2'-[propane-2,2-diylbis(4,1-phenyleneoxymethylene)]dioxirane
- Details on test material:
- Test substance- 1675-54-3
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Details on inhalation exposure:
- Single inhalation exposure, 5 hours
Substantially saturated atmosphere generated by allowing open vessel to equilibrate in 19 L glass jar exposure chamber (assumed to be maximum attainable concentration)
6 animals/dose level, usually male albino rats
14-day observation period - Duration of exposure:
- 5 h
- Concentrations:
- 0.000008 ppm (saturated atmosphere)
Saturated atmosphere was calculated based on a vapor pressure of 0.0006 e-6 at 25C and 760 mmHg to be 7.89ppt. - No. of animals per sex per dose:
- Six males
- Control animals:
- no
- Details on study design:
- Six males were exposed for 5 hours to a substantially saturated atmosphere, then observed for 14 days. Mortality and clinical signs were recorded. Test was terminated after 14 days. Animals were not examined post-mortem.
- Statistics:
- N/A
Results and discussion
Effect levels
- Dose descriptor:
- LC0
- Effect level:
- 0 ppm
- Exp. duration:
- 5 h
- Remarks on result:
- other: LC0= 0.000008 ppm
- Mortality:
- Breathing saturated vapors was not fatal to rats during a five-hour exposure.
- Clinical signs:
- other: None recorded.
- Body weight:
- No effect
- Gross pathology:
- Examination not conducted.
Applicant's summary and conclusion
- Conclusions:
- The LC0 in rats is ~0.000008 ppm.
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