Barium phosphinate

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the closely related read across chemicals.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

WoE report was prepared based on toxicity study of test chemical to aquatic algae.

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: Chlorococcales and Skeletonema costatum

Details on test organisms:

2. Details on test organisms
TEST ORGANISM
- Common name: Green Algae Order

3. Details on test organisms
TEST ORGANISM
- Common name: Diatom

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Remarks on exposure duration:

Toxicity of test chemical was also studied after providing exposure period of 24 hrs.

Reference substance (positive control):

not specified

Key result

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: Assimilation efficiency

Remarks on result:

other: Other details not known

Key result

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

500 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: Reduction in Chlorophyll A concentration

Remarks on result:

other: Other details not known

Validity criteria fulfilled:

not specified

Conclusions:

By applying weight of evidence approach the EC 50 value if test chemical is expected to be in range from 500 to 1000 mg/L after exposure of test chemical for 24-96 hrs. The EC50 value indicates that the substance is likely to be nonhazardous to aquatic algae and cannot be classified as per the CLP classification criteria.

Executive summary:

Summarized studies of the test chemical on the growth and other biological activity of aquatic algae were studied. The studies are as mentioned below:

 

Aim of this study was to investigate the effect of test chemical on the growth of aquatic algae. Test conducted under the static system continued for 24 hrs. Based on the effects observations on assimilation efficiency of Chlorococcales (Green Algae Order) after the exposure of test chemical for 24 hrs, the EC50 was determine to be 1000 mg/l. Thus on the basis of EC50 value, chemical was consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

Similar study was also performed to determine the toxicity of test chemical. Principle of this study was to investigate the effect of test chemical on the growth of aquatic algae and cyanobacteria. Test conducted under the static system for 96 hrs of exposure with chemical. Based on the reduction in Chlorophyll A concentration of Skeletonema costatum (Diatom) by the chemical exposure for 96 hrs, the EC50 was determine to be 500 mg/l. Thus based on the EC50 value, chemical was consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

Thus based on the overall studies for the test chemical from various sources, it is concluded that the test chemical was nontoxic and not classified as per the CLP classification criteria.

Description of key information

By applying weight of evidence approach the EC 50 value if test chemical is expected to be in range from 500 to 1000 mg/L after exposure of test chemical for 24-96 hrs. The EC50 value indicates that the substance is likely to be nonhazardous to aquatic algae and cannot be classified as per the CLP classification criteria

Key value for chemical safety assessment

EC50 for freshwater algae:

1 000 mg/L

Additional information

Summarized studies of the test chemical and closest similar read across chemical on the growth and other biological activity of aquatic algae were studied. The studies are as mentioned below:

 

Aim of this study was to investigate the effect of test chemical on the growth of aquatic algae. Test conducted under the static system continued for 24 hrs. Based on the effects observations on assimilation efficiency of Chlorococcales (Green Algae Order) after the exposure of test chemical for 24 hrs, the EC50 was determine to be 1000 mg/l. Thus on the basis of EC50 value, chemical was consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

Similar study was also performed to determine the toxicity of test chemical. Principle of this study was to investigate the effect of test chemical on the growth of aquatic algae and cyanobacteria. Test conducted under the static system for 96 hrs of exposure with chemical. Based on the reduction in Chlorophyll A concentration of Skeletonema costatum (Diatom) by the chemical exposure for 96 hrs, the EC50 was determine to be 500 mg/l. Thus based on the EC50 value, chemical was consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.

 

Thus based on the overall studies for the test chemical from various sources, it is concluded that the test chemical was nontoxic and not classified as per the CLP classification criteria.