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EC number: 218-658-4
CAS number: 2212-32-0
An acute oral toxicity study is available; waivers are provided for
acute dermal toxicity and acute inhalation toxicity, based on the
corrosivity of the substance.
Mortality (out of 5/sex/dose)
Dose (mg/kg bw)
Total after 15 days
Mean weight (g)
214 ± 8.1
248 ± 11
279 ± 14
193 ± 5.4
205 ± 7.7
180 ± 3.7
213 ± 6.9
185 ± 13
≤ 24 hours
≤ 6 days
2 – 5 h
Curved body position
≤ 5 days
≤ 48 hours
Central body position
An acute oral toxicity was conducted in rats according to OECD 401 and
EU methods B.1. N, N, N Trimethylaminoethyl-Ethanolamin was adminstered
by oral gavage to 5 rats/sex/group at dose levels of 2000, 3200 and 5000
mg/kg bw. Mortality was observed at all doses; all animals dosed with
5000 mg/kg bw died, seven animals dosed with 3200 mg/kg bw died and one
animal dosed with 2000 mg/kg bw died. Clinical signs included sedation,
curved body position, ruffled fur, somnolence, ataxia and tremors. In
those animals which died during the study, red discoloration of the
lungs, stomach and intestines filled with test article and/or red fluid,
red discolouration of the stomach and intestines and enlargemet of the
stomach and intestines were observed. No pathological changes were noted
in animals surviving to the scheduled termination. The LD50 values were
3081 mg/kg bw (males), 2570 mg/kg bw (females) and 2801 mg/kg bw
(combined males and females). In accordance with CLP, classification for
acute oral toxicity is not required.
Waivers are provided for acute dermal toxicity and acute inhalation
toxicity, based on the corrosivity of the substance.
No classification for acute oral toxicity is required, based on the
available study. LD50 values are reported to be >2000 mg/kg bw;
therefore classification under CLP is not required.
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