Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 271-928-3 | CAS number: 68630-95-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- other: not specified
Test material
- Reference substance name:
- 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-nortall-oil alkyl derivs.
- EC Number:
- 263-171-2
- EC Name:
- 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-nortall-oil alkyl derivs.
- Cas Number:
- 61791-39-7
- Molecular formula:
- UVCB. Not applicable (a generic molecular formula cannot be provided for this specific UVCB substance).Average Empirical Formula: C H N O 22 40-44
- IUPAC Name:
- 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-nortall-oil alkyl derivs
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Alkyl imidazoline is a UVCB material contininag structures which are very similar to the substance under test.
There are no studies for this substance and due to a ban on animal testing for such end points, it is necessry to try to find an alternative way of making an assessment using other substances that have been tested in-vivo in previous years.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 213 - <= 2 546 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 1 259 - <= 2 638 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 1 515 - <= 2 349 mg/kg bw
Any other information on results incl. tables
Alkyl imidazoline, 1-(2-Hydroxyethyl)-2-alkyl*-2-imidazoline (*as in fatty acids of tall oil), has been tested in the following acute toxicity
tests. With Sprague-Dawley rats (MRID No. 42293001), alkyl imidazoline demonstrated an acute oral LD of 1948 (1259-2638) mg/kg body weight 50 for male rats, 1880 (1213-2546) mg/kg for female rats, and 1932 (1515 - 2349) mg/kg for combined sexes.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Alkyl imidazoline is a UVCB material contininag structures which are very similar to the substance under test.
There are no studies for this substance and due to a ban on animal testing for such end points, it is necessry to try to find an alternative way of making an assessment using other substances that have been tested in-vivo in previous years.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
