Registration Dossier
Registration Dossier
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EC number: 231-411-5 | CAS number: 7538-59-2
Endpoint summary
Administrative data
Description of key information
Biodegradation:
Biodegradation in water:
Estimation Programs Interface Suite (EPI suite, 2019) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be not readily biodegradable.
Additional information
Biodegradation:
Biodegradation in water:
Predicted data study for target chemical and experimental studies for its structurally similar read across chemical have been reviewed for biodegradation in water endpoint and their results are summarized below.
In first study the Estimation Programs Interface Suite (EPI suite, 2019) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be not readily biodegradable.
Next study was experimental study reviewed from the authoritative databases and a secondary source in this study biodegradation experiment was conducted for 28 days to determine the percentage biodegradability of test substance. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I) under aerobic conditions. Activated sludge (non-adapted) was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test chemical was determined to be 10% and 0% by O2 consumption (BOD) and test material analysis by HPLC parameter respectively in 28 days. Thus, based on percentage degradation, test substance was considered to be not readily biodegradable in water.
In another experimental study the Manometric respirometry test following the OECD guideline 301F was performed to determine the ready biodegradability of the test chemical. The test system included control, test chemical and reference chemical. The concentration of test and reference chemical ( Sodium Benzoate) chosen for both the study was 30 mg/L, while that of inoculum was 10 ml/l. ThOD (Theoretical oxygen demand) of test chemical and reference chemical was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for test chemical. The BOD28 value of test chemical was observed to be 0.188 mgO2/mg. ThOD was calculated as 1.464 mgO2/mg. accordingly, the % degradation of the test chemical after 28 days of incubation at 20 ± 1°C according to manometric respirometry test was determined to be 12.807 %. Based on the results, the test chemical, under the test conditions, was considered to be not readily biodegradable at 20± 1°C over a period of 28 days.
Last study was also reviewed from authoritative database in this study the test chemical was subjected to biodegradation test by taking activated sludge as inoculums at 30 mg/L concentration. Biodegradation was analysed by using O2 consumption (BOD) parameter. The initial concentration of test chemical was 100 mg/L. After 2 weeks (14 days) on incubation test chemical showed 0 % biodegradability by O2 consumption (BOD) parameter. On the basis of percent degradation value it is concluded that test chemical is not readily biodegradable.
On the basis of results of all the studies mentioned above it can be concluded that test chemical is not readily biodegradable in nature.
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