Registration Dossier
Registration Dossier
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EC number: 244-942-2 | CAS number: 22374-89-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity study of test chemical in rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity of test chemical in rat
- Author:
- Jay A. Brown
- Year:
- 2 017
- Bibliographic source:
- Haz-Map®: Information on Hazardous Chemicals and Occupational Diseases, U.S. National Library of Medicine
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity study of test chemical in rats
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- Anisole
- EC Number:
- 202-876-1
- EC Name:
- Anisole
- Cas Number:
- 100-66-3
- Molecular formula:
- C7H8O
- IUPAC Name:
- methoxybenzene
- Details on test material:
- - Name of test material (IUPAC name): Anisol
- Common name: Methoxybenzene
- Molecular formula: C7H8O
- Molecular weight: 108.1392 g/mol
- Smiles notation: COc1ccccc1
- InChl: 1S/C7H8O/c1-8-7-5-3-2-4-6-7/h2-6H,1H3
- Substance type: Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Concentrations:
- 5 mg/l in air (5000 mg/m3)
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 5 mg/L air
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at dose 5 mg/l in air in treated rats
- Clinical signs:
- other: No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The acute inhalation toxicity dose (LC50) was considered to be >5000 mg/ m3 (>5 mg/L) when rats were exposed with test chemical by inhalation route.
- Executive summary:
The acute inhalation toxicity study was conducted by using test chemical in rats at the concentration of 5000 mg/m3 inhaled as a Single dose. No mortality was observed at 5000 mg/m3. Therefore, LC50 value was considered to be >5000 mg/ m3 (>5 mg/L) when rats were exposed with test chemical by inhalation route.
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