Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Skin Irritation:

The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6 Hence this endpoint was considered for waiver.

Eye Irritation:

The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6 Hence this endpoint was considered for waiver.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
Justification for type of information:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6. Hence this endpoint was considered for waiver
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
Justification for type of information:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6. Hence this endpoint was considered for waiver.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin Irritation:

The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6 Hence this endpoint was considered for waiver.

Eye Irritation:

The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6 Hence this endpoint was considered for waiver.

Justification for classification or non-classification

According to the CLP Regulation (EC n. 1272/2008) and based on the high pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) (pH= 11.6), the classificationSkin Corrosive 1B and Eye Damage 1 isproposed for 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6).