Registration Dossier
Registration Dossier
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EC number: 232-266-0 | CAS number: 7803-65-8
Endpoint summary
Administrative data
Description of key information
The test chemical did not induce contact senstization on humans and guinea pigs when tested in skin sensitization est. Hence the test chemical is considered to be not sensitizing to the skin
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental data from various test chemicals
- Justification for type of information:
- Data for the target chemical is summarized based on data from various test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- WoE for the target CAS is summarized based on data from various test chemicals
- GLP compliance:
- not specified
- Type of study:
- other: 2. Patch test; 3. No data
- Justification for non-LLNA method:
- Not Specified
- Species:
- other: 2. Human; 3. Guinea pigs
- Strain:
- other: Not applicable
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Urea
- Remarks:
- 2
- Concentration / amount:
- No data available
- Day(s)/duration:
- 46 hours
- Adequacy of induction:
- not specified
- Route:
- other: No data available / 3
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: urea
- Remarks:
- 2
- Concentration / amount:
- No data available
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- not specified
- Route:
- other: No data available / 3
- No. of animals per dose:
- No data available
- Details on study design:
- No data available
- Challenge controls:
- No data available
- Reading:
- 1st reading
- Hours after challenge:
- 46
- Group:
- test chemical
- Dose level:
- No data available / 2
- No. with + reactions:
- 0
- Clinical observations:
- The chemical did not cause skin sensitization.
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- 2
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- No data available / 3
- No. with + reactions:
- 0
- Clinical observations:
- The chemical did not cause skin sensitization in the guinea pigs.
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- The test chemical did not induce contact senstization on humans and guinea pigs when tested in skin sensitization est. Hence the test chemical is considered to be not sensitizing to the skin.
- Executive summary:
Data available for the various test chemicals was reviewed to determine the skin sensitization study of the test chemical. The studies are as mentioned below:
Patch-Test was conducted on humans to determine the degree of contact sensitization caused by the chemical. An aqueous solution of the test chemical (with urea) was negative when applied in a 46-h exposure human skin patch test. The test chemical did not induce contact senstization on humans when tested in a 46-h exposure human skin patch test. Hence the test chemical is considered to be not sensitizing to the skin of human subjects.
In another study, the skin sensitization study of test chemical was studied using guinea pigs to determine the skin sensitization potential of test chemical. When the test chemical was applied dermally to the skin of guinea pig, none of the treated guinea pigs showed the induction of skin sensitization. Hence the test chemical was considered to be not sensitizing to the skin of guinea pig.
.
Based on the data available and applying trhe weight of evidence approach, the test chemical did not induce contact senstization on humans and guinea pigs when tested in skin sensitization test. Hence the test chemical is considered to be not sensitizing to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Data available for the various test chemicals was reviewed to determine the skin sensitization study of the test chemical. The studies are as mentioned below:
Patch-Test was conducted on humans to determine the degree of contact sensitization caused by the chemical. An aqueous solution of the test chemical (with urea) was negative when applied in a 46-h exposure human skin patch test. The test chemical did not induce contact senstization on humans when tested in a 46-h exposure human skin patch test. Hence the test chemical is considered to be not sensitizing to the skin of human subjects.
In another study, the skin sensitization study of test chemical was studied using guinea pigs to determine the skin sensitization potential of test chemical. When the test chemical was applied dermally to the skin of guinea pig, none of the treated guinea pigs showed the induction of skin sensitization. Hence the test chemical was considered to be not sensitizing to the skin of guinea pig.
.
Based on the data available and applying trhe weight of evidence approach, the test chemical did not induce contact senstization on humans and guinea pigs when tested in skin sensitization test. Hence the test chemical is considered to be not sensitizing to the skin
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the data available and applying trhe weight of evidence approach, the test chemical did not induce contact senstization on humans and guinea pigs when tested in skin sensitization test. Hence the test chemical is considered to be not sensitizing to the skin
From the results obtained from these studies it is concluded that the chemical Ammonium phosphinate (CAS No: 7803-65-8) is not likely to cause skin sensitization and hence can be classified as non-skin sensitizer.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
