Registration Dossier
Registration Dossier
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EC number: 618-892-0 | CAS number: 92972-47-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Experimental data on germ cell mutagenicity of TAT-1 are not available.
QSAR Toolbox has identified as structural alert for this property the "H-acceptor-path3-H-acceptor" (mechanistic profile). This alert explores the possibility that a chemical interacts with DNA and/or proteins via non-covalent binding, such as DNA intercalation or groove-binding (Snyder et al. 2006). Among the descriptors potentially accounting for non-covalent interactions, the present molecular framework representing two bonded atoms connecting two H bond acceptors (calculated with software Leadscope Enteprise 2.4.15-6) resulted in an increased sensitivity/specificity for what concerns the Micronucleus training set.
Endpoint conclusion
- Endpoint conclusion:
- no study available
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Experimental data on germ cell mutagenicity of TAT-1 are not available.
QSAR Toolbox has identified as structural alert for this property the "H-acceptor-path3-H-acceptor" (mechanistic profile)
Overall, available information are judged as inconclusive for the classification of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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